55077-30-0

Crystals. Melting point 189-191℃.

Abovis ,Toyama ,Japan ,1981

Aclatonium Napadisilate is a useful bioactive therapeutic agent for autoimmune diseases. A cholinergic agonist.

5.2 g of bis(choline)-naphthalene-1,5-disulfonate was suspended in 30 ml of acetonitrile, and 10 g of lactic acid anhydride diacetate was added thereto. This mixture was refluxed for 3 hours. The resulting reaction mixture was allowed to stand at room temperature while cooling to precipitate the desired product crystals, which were collected by filtration. 5.5 g (76% yield) of the desired product having a melting point of 189°C to 191°C were obtained.

Cholinergic

Poison by intravenous route.Moderately toxic by subcutaneous route. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx andSOx. A cholinergic agent.