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506-68-3

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Identification

Name
Cyanogen bromide
CAS
506-68-3
Synonyms
BROMINE CYANIDE
BROMOCYAN
BROMOCYANE
BROMOCYANIDE
CYANOGEN BROMIDE
(CN)Br
BrCN
Bromine cyanide(BrCN)
Bromine monocyanide
brominecyanide(brcn)
Bromocyanide(BrCN)
Bromocyanogen
Bromure de cyanogen
bromuredecyanogen
bromuredecyanogen(french)
bromuredecyanogene
Campilit
Cyanic bromide
Cyanobromide
Cyanogen bromide ((CN)Br)
EINECS(EC#)
208-051-2
Molecular Formula
CBrN
MDL Number
MFCD00011597
Molecular Weight
105.92
MOL File
506-68-3.mol

Chemical Properties

Appearance
Cyanogen bromide is a colorless or white, volatile, crystalline solid with a penetrating odor.
Appearance
white crystalline solid
Melting point 
50-53 °C(lit.)

mp 
50-53 °C(lit.)

Boiling point 
61-62 °C(lit.)

bp 
61-62 °C(lit.)

density 
1.443 g/mL at 25 °C

vapor density 
3.65 (vs air)

vapor pressure 
100 mm Hg ( 22.6 °C)

refractive index 
1.4670 (estimate)
Fp 
61.4°C
storage temp. 
0-6°C
solubility 
Soluble in chloroform, dichloromethane, ethanol, diethyl ether, benzene and acetonitrile.
form 
Solution
color 
White
Stability:
Stable. Reacts violently with water and with mineral and organic acids.
Water Solubility 
decomposed slowly by cold H2O [HAW93]
Sensitive 
Moisture & Light Sensitive
Merck 
14,2693
CAS DataBase Reference
506-68-3(CAS DataBase Reference)
NIST Chemistry Reference
Cyanogen bromide(506-68-3)
EPA Substance Registry System
506-68-3(EPA Substance)

Hazard Information

Chemical Properties
Cyanogen bromide is a colorless or white, volatile, crystalline solid with a penetrating odor.
Chemical Properties
white crystalline solid
Uses
Reaction with C60Ph5Cl produces a novel phenylated isoquinolino[3′,4′:1,2][60]fullerene.1
Uses
Reagent for the synthesis of cyanamides.
General Description
CYANOGEN BROMIDE(506-68-3) is a colorless to white crystalline solid with a penetrating odor. CYANOGEN BROMIDE(506-68-3) is slightly soluble in water. CYANOGEN BROMIDE(506-68-3) is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a flammable and poisonous gas. Contamination with many materials can cause rapid decomposition of the material. CYANOGEN BROMIDE(506-68-3) is toxic by inhalation of its vapors or by the hydrogen cyanide from decomposition or by ingestion. Toxic oxides of nitrogen are produced in fire involving this material. CYANOGEN BROMIDE(506-68-3) is used in gold extraction, to make other chemicals, and as a fumigant.
Reactivity Profile
CYANOGEN BROMIDE is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. [EPA, 1998]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).
Air & Water Reactions
CYANOGEN BROMIDE is slightly soluble in water. CYANOGEN BROMIDE is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a poison gas.
Health Hazard
Exposure to cyanogen bromide is dangerous. The chemical substance is poisonous and causes fatal injury if swallowed, inhaled, or absorbed through the skin. It is corrosive and the vapors cause severe irritation to the eyes and respiratory tract, and cause burns to any area of contact. On contact with acids, cyanogen bromide liberates poisonous gas, affecting the blood, cardiovascular system, CNS, and thyroid.
Health Hazard
Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. Vapors are highly irritant and very poisonous. Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects.
Potential Exposure
Used as an activating reagent for insoluble supports for affinity absorption. In danger are those manufacturing this compound or using it in organic synthesis or as a fumigant; in textile treatment; in gold cyaniding. It may have been used as a military poison gas.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek Medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immedi- ately with soap and water. Seek medical attention immedi- ately. Do not perform direct mouth to mouth resuscitation; use bag/mask apparatus. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using uni- versal precautions, including resuscitation mask) if breath- ing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is con- scious, administer water or milk. Do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.br Use amyl nitrate capsules if symptoms of cyanide poison- ing develop. All area employees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidote kit should be kept in the immediate work area and must be rapidly available. Kit ingredients should be replaced every 1 2 years to ensure freshness. Persons trained in the use of this kit; oxygen use, and CPR must be quickly available.
Fire Hazard
Cyanogen bromide is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Vapors are highly irritating. When material is heated to decomposition, CYANOGEN BROMIDE emits very toxic fumes of cyanide and bromide. Avoid water, acids. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control.
Shipping
UN1889 Cyanogen bromide, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. A DOT regulated marine pollutant.
Incompatibilities
May be unstable unless dry and pure; impure cyanogen bromide decomposes rapidly and tends to explode. Cyanogen bromide decomposes violently on heat- ing or on contact with water, acids, or acid vapors; produc- ing highly toxic and flammable hydrogen cyanide and corrosive hydrogen bromide. Avoid physical damage, con- tact with acids or water, and store away from a location where water may be needed for fire control . Violent reaction with ammonia, amines.
Waste Disposal
May be added to strong alka- line solution of calcium hypochlorite, let stand for 24 hours and flush to sewer. May also be dissolved in flammable solvent and sprayed into an incinerator equipped with after- burner and scrubber.
Purification Methods
All operations with this substance should be performed in a very efficient fume cupboard-it is very POISONOUS and should be handled in small amounts. Fresh commercial material is satisfactory for nearly all purposes and does not need to be purified. It is a white crystalline solid with a strong cyanide odour. If it is reddish in colour and partly liquid or paste-like, then it is too far gone to be purified, and fresh material should be sought. It can be purified by distillation using small amounts at a time, and using a short wide-bore condenser because it readily solidifies to a crystalline white solid which may clog the condenser. An appropriate gas mask should be used when transferring the molten solid from one container to another, and the operation should be done in an efficient fume cupboard. The melting point (m 49-51o) should be measured in a sealed tube. [Hartman & Dreger Org Synth Coll Vol II 150 1948.]

Safety Data

Hazard Codes 
T+,N,F,C
Risk Statements 
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R40:Limited evidence of a carcinogenic effect.
R11:Highly Flammable.
R36/37:Irritating to eyes and respiratory system .
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place .
RIDADR 
UN 3390 6.1/PG 1

WGK Germany 
3

RTECS 
GT2100000


8-17-19-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
28530090
Safety Profile
A human and experimental poison by inhalation. Corrosive. When heated to decomposition it emits very toxic fumes of CNand Br-. Possibly unstable. See also other cyanogen entries; CYANIDE; and BROMIDES.
Hazardous Substances Data
506-68-3(Hazardous Substances Data)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

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