50-34-0

Name	Propantheline bromide
CAS	50-34-0
EINECS(EC#)	200-030-6
Molecular Formula	C23H30BrNO3
MDL Number	MFCD00050291
Molecular Weight	448.39
MOL File	50-34-0.mol

Chemical Properties

Appearance	white crystalline powder
Melting point	159-161°C
density	1.2916 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	Refrigerator
solubility	H2O: soluble50mg/mL
form	powder
color	white to off-white
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	>=10 g/100 mL at 21 ºC
EPA Substance Registry System	2-Propanaminium, N-methyl-N-(1-methylethyl)- N-[2-[(9H-xanthen-9-ylcarbonyl) oxy]ethyl]-, bromide(50-34-0)

Safety Data

Hazard Codes	Xn
Risk Statements	22 less more
Safety Statements	36 less more
WGK Germany	3
RTECS	BP8249200
HS Code	2932992000

Raw materials And Preparation Products

Hazard Information

Chemical Properties

white crystalline powder

Uses

A muscarinic acetylcholine receptor antagonist

Uses

anticholinergic

Uses

Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder.

General Description

White crystals or white powder. Melting point 159-161°C .Used therapeutically as an anticholinergic.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma.

Fire Hazard

Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible.

Definition

ChEBI: Propantheline bromide is a member of xanthenes.

Brand name

Pro-Banthine (Searle).

Biochem/physiol Actions

Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion.

Veterinary Drugs and Treatments

In small animal medicine propantheline bromide has been used for its antispasmodic/antisecretory effects in the treatment of diarrhea. It is also employed in the treatment of hyperreflexic detrusor or urge incontinence and as oral treatment in anticholinergic responsive bradycardias. In horses, propantheline has been used intravenously to reduce colonic peristalsis and for relaxing the rectum to allow easier rectal examination and surgery.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Supplier

Hubei Chenxin Pharmaceutical Co., Ltd.

Telephone 18696113233

Websitehttp://www.chenxinyaoye.cn

Jiangxi ravel Biotechnology Co.,Ltd

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Websitehttps://www.ruiweier.cn/

J & K SCIENTIFIC LTD.

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Websitehttp://www.jkchemical.com

CHANGZHOU TIANHUA PHARMACEUTICAL CO.，LTD.

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Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Tianjin heowns Biochemical Technology Co., Ltd.

Telephone400 638 7771

Websitehttp://www.heowns.com

Sinopharm Chemical Reagent Co,Ltd.

Telephone86-21-63210123

Websitehttp://www.reagent.com.cn

Aemon Chemical

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Websitehttp://www.aemonchem.com

Hangzhou Yuhao Chemical Technology Co., Ltd

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Websitehttp://www.chemyuhao.com

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810

Websitehttp://www.sunlidabio.com

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

ChemStrong Scientific Co.,Ltd

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Websitehttp://www.chem-strong.com

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Telephone0510-85629785 18013409632

Websitehttp://www.reading-chemicals.com

Wuhan Dahua Pharmaceutical Co., Ltd.

Telephone027-59262863 13277907145 3091977954

Websitehttp://show.chemicalbook.com/whdhwy01/

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Telephone027-59420981,18702770802

Websitehttp://www.whdhwy.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Henan CoreyChem Co., Ltd

Telephone0371-86658258

Websitehttp://www.coreychem.com

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