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• Synthesis

  In a dry reaction flask, add Boc anhydride (0.8 mmol) and ethanol (3.5 mL), then cool the reaction mixture to an ice bath. Slowly add 70% ammonia solution (0.6 mL) dropwise to the reaction system. Stir the mixture at approximately 0 °C for 1 hour, then transfer the reaction mixture to room temperature and stir at room temperature for 18 hours. After the reaction is complete (monitored by TLC), heat the reaction mixture at 50 °C to evaporate the organic solvent. Dissolve the resulting residue in n-hexane (10 mL), then heat the mixture at 60 °C for 1 hour. Purify the mixture by recrystallization from the cooled n-hexane to obtain tert-butyl carbamate.

  

  Figure: Synthetic Route of Tert-Butyl Carbamate

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