ChemicalBook CAS DataBase List 3647-69-6

3647-69-6

Name	4-(2-Chloroethyl)morpholine hydrochloride
CAS	3647-69-6
EINECS(EC#)	222-881-2
Molecular Formula	C6H13Cl2NO
MDL Number	MFCD00012797
Molecular Weight	186.08
MOL File	3647-69-6.mol

Synonyms

2-CHLOROETHYLMORPHOLINE HYDROCHLORIDE 2-MORPHOLINOETHYL CHLORIDE HYDROCHLORIDE 4-(2-CHLOROETHYL)MORPHOLINE HYDROCHLORIDE MOCPRF MORPHOLINOETHYL CHLORIDE HYDROCHLORIDE N-(2-CHLORETHYL)-MORPHOLINIUM CHLORIDE N-(2-CHLOROETHYL)MORPHOLINE HYDROCHLORIDE 4-(2-chloroethyl)-morpholinhydrochloride 4-(2-chloroethyl)morpholinium chloride N-(2-Chloroethyl)morpholine HCl 2-ChloroethylmorpholineHcl98% 2-Chloroethylmorpholine Hcl 98% N-(2-Chloroethyl)morpholineHCl,[2-(N-Morpholino)ethylchlorideHCL] MOC 2-(n-morpholino)ethyl chloride hydrochloride N-(2-Chloroethyl)morpholine hydrochloride 99% N-morpholinoethylchloride hydrochloride 1-Chloro-2-morpholinoethanehydrochloride 2-(4-Morpholinyl)ethyl chloride hydrochloride Morpholine, 4-(2-chloroethyl)-, hydrochloride

Chemical Properties

Appearance	White to beige crystalline powder
Melting point	180-185 °C (dec.)(lit.)
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form	Hygroscopic Crystalline Powder
color	White to beige
PH	4.5-5 (10g/l, H2O, 20℃)
Water Solubility	soluble
Sensitive	Hygroscopic
Usage	4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). Product Data Sheet
BRN	3684083
InChI	InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H
InChIKey	NBJHDLKSWUDGJG-UHFFFAOYSA-N
SMILES	C1OCCN(CCCl)C1.[H]Cl
CAS DataBase Reference	3647-69-6(CAS DataBase Reference)
EPA Substance Registry System	3647-69-6(EPA Substance)

Safety Data

Symbol(GHS)	GHS05,GHS06,GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H312-H314-H317-H412-H301-H312-H314-H317-H412
Precautionary statements	P260-P273-P280-P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes	T
Risk Statements	R21:Harmful in contact with skin. R25:Toxic if swallowed. R34:Causes burns. R43:May cause sensitization by skin contact. R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S61:Avoid release to the environment. Refer to special instructions safety data sheet . less more
RIDADR	UN 2923 8/PG 3
WGK Germany	2
RTECS	QE0260000
Autoignition Temperature	365 °C
TSCA	Yes
REACH Registrations	Active
HazardClass	8
PackingGroup	III
HS Code	29349990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Acute Tox. 4 Dermal Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1B Skin Sens. 1
Safety Profile	Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. less more
Toxicity	LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White to beige crystalline powder

Uses

4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). Product Data Sheet

Uses

4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl obin aggregation inhibiting-activity.

Synthesis

110-91-8

107-07-3

4-(2-Chloroethyl)morpholine hydrochloride

3647-69-6

General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride.

References

[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Shaoxing Hongda Medical Technology Co.,Ltd

Telephone 18072995930

Websitehttps://www.chemicalbook.com/supplier/24879456/

Jiangsu Chromene New Material Technology Co., Ltd

Telephone 15358977508

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList466513/0_EN.htm

NINGBO JL NEW MATERIAL CO.,LTD

Telephone0574 88552216 19032109677

Websitehttps://www.chematerials.cn

Jinan Dexinjia Bio&Tech Co., Ltd

Telephone0531-82375878 15064153060

Websitehttp://www.jndxj.com

Shanghai Qiao Chemical Science Co., Ltd

Telephone021-58892003 18601689453;

Websitehttps://www.chemicalbook.com/supplier/10168672/1.htm

XIANBAISI BIOPHARMACEUTICAL

Telephone 19109577350

Website

Wuhan WinYuanBei Trading Company

Telephone86-13349903920 13349903920

Websitehttp://www.yyb-chem.com

J & K SCIENTIFIC LTD.

Telephone18210857532; 18210857532

Websitehttps://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

TAIYUAN RHF CO.,LTD.

Telephone+86 351 7031519

Websitehttp://www.rhfchem.com/

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Beijing dtftchem Technology Co., Ltd.

Telephone010-60275820 13031183356

Websitehttp://www.dtfchem.com

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

JinYan Chemicals(ShangHai) Co.,Ltd.

Telephone13817811078

Websitehttp://www.jingyan-chemical.com/

Jia Xing Isenchem Co.,Ltd

Telephone0573-85285100 18627885956

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm

1of4

Related Products

Send Inquriy