2935-90-2

Methyl 3-mercaptopropionate is a thiol compound that can be used as a photochemical functionalisation reagent. For example, it enables photochemical functionalisation of 1,4-polymyrcene compounds via the reversibility of thiol-alkene reactions. It is also frequently employed as a spectroscopic probe molecule in molecular dynamics studies.

CLEAR COLORLESS LIQUID

Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.

Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.

Nonflammable

The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.

[1] Patent: US2005/49234, 2005, A1. Location in patent: Page/Page column 6
[2] Russian Chemical Bulletin, 2009, vol. 58, # 2, p. 457 - 467
[3] Collection of Czechoslovak Chemical Communications, 1975, vol. 40, p. 3688 - 3697
[4] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 7, p. 535 - 540