ChemicalBook CAS DataBase List 367-51-1

367-51-1

Name	Sodium thioglycolate
CAS	367-51-1
EINECS(EC#)	206-696-4
Molecular Formula	C2H3NaO2S
MDL Number	MFCD00043386
Molecular Weight	114.1
MOL File	367-51-1.mol

Synonyms

MERCAPTOACETIC ACID SODIUM SALT NATG SODIUM MERCAPTOACETATE SODIUM THIOGLYCOLATE SODIUM THIOGLYCOLLATE THIOGLYCOLIC ACID SODIUM SALT Aceticacid,mercapto-,monosodiumsalt Mercaptoaceticacidmonosodiumsalt mercapto-aceticacimonosodiumsalt thioglycolatedesodium thioglycolatesodium thioglycollicacid,sodiumsalt usafek-5199 Sodium thiobycliate SODIUM THIOGLYKOLATE SODIUME THINOBYCLIATE SodiumThioglycollate,>96% SodiumThioglycollateForBacteriology SODIUM THIOGLYCOLATE (FOR BACTERIOLOGY) Mercaptoaceticacidsodiumsalt,97%

Chemical Properties

Definition	The sodium salt of thioglycolic acid.
Appearance	White solid
Melting point	>300 °C (lit.)
bulk density	200kg/m3
vapor pressure	<0.1 hPa (25 °C)
storage temp.	2-8°C
solubility	609.1g/l
form	solid
pka	3.82[at 20 ℃]
color	White powder
Odor	Stench odour
PH	6.7 (100g/l, H2O, 20℃)
PH Range	6.5 - 8 at 114 g/l at 25 °C
Water Solubility	soluble
Sensitive	Air Sensitive & Hygroscopic
Merck	14,8692
BRN	4569109
Exposure limits	ACGIH: TWA 1 ppm (Skin)
Cosmetics Ingredients Functions	REDUCING HAIR WAVING OR STRAIGHTENING DEPILATORY ANTIOXIDANT
InChI	1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1
InChIKey	GNBVPFITFYNRCN-UHFFFAOYSA-M
SMILES	[Na+].[O-]C(=O)CS
LogP	-2.99 at 20℃
CAS DataBase Reference	367-51-1(CAS DataBase Reference)
EPA Substance Registry System	367-51-1(EPA Substance)

Safety Data

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H290-H301-H312-H317
Precautionary statements	P234-P261-P264-P280-P301+P310-P302+P352+P312
Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R38:Irritating to the skin. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S36:Wear suitable protective clothing . S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
RIDADR	2811
WGK Germany	1
RTECS	AI7700000
F	3-10-13-23
TSCA	Yes
REACH Registrations	Active
HazardClass	6.1(b)
PackingGroup	III
HS Code	29309070
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Acute Tox. 4 Dermal Aquatic Chronic 3 Met. Corr. 1 Skin Sens. 1B
Safety Profile	Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS. less more
Toxicity	LD50 i.p. in rats: 148 mg/kg, Freeman, Rosenthal, Fed. Proc. 11, 347 (1952) less more

Hazard Information

General Description

White powder with a slight odor. Used in cold-waving of hair and as a dipilatory.

Reactivity Profile

THIOGLYCOLIC ACID, SODIUM SALT(367-51-1) is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.

Air & Water Reactions

Hygroscopic. Discolors on exposure to air. Water soluble.

Hazard

Yields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.

Fire Hazard

Flash point data for this chemical are not available. THIOGLYCOLIC ACID, SODIUM SALT is probably combustible.

Chemical Properties

White solid

Uses

dipilatory, irritant, chelating agent

Uses

In cold-waving of hair; as depilatory; in bacteriology for the preparation of thioglycolate media; as analytical reagent, see Thioglycolic Acid.

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Purification Methods

It crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

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