ChemicalBook CAS DataBase List 60-24-2

60-24-2

Name	2-Mercaptoethanol
CAS	60-24-2
EINECS(EC#)	200-464-6
Molecular Formula	C2H6OS
MDL Number	MFCD00004890
Molecular Weight	78.13
MOL File	60-24-2.mol

Chemical Properties

Appearance	Clear colorless liquid
Melting point	-100 °C
Boiling point	157 °C (lit.)
density	1.115 g/mL at 20 °C
vapor density	2.69 (vs air)
vapor pressure	1 mm Hg ( 20 °C)
FEMA	4582 \| 2-HYDROXYETHANETHIOL
refractive index	n20/D 1.500(lit.)
Fp	165 °F
storage temp.	2-8°C
solubility	H₂O: 1 mL/mL
form	liquid
pka	9.72(at 25℃)
color	Clear colorless to slightly yellow
Specific Gravity	1.119 (20/4℃)
Odor	Disagreeable odor
PH	4.5-6 (500g/l, H2O, 20℃)
PH Range	4.5 - 6 at 500 g/l at 20 °C
explosive limit	2.3-18%(V)
Water Solubility	soluble
FreezingPoint	<100℃
Sensitive	Air Sensitive & Hygroscopic
λmax	λ: 260 nm Amax: 1.5 λ: 280 nm Amax: 0.3
JECFA Number	1925
Merck	14,5869
BRN	773648
Henry's Law Constant	5.5×10¹ mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Stability:	Air Sensitive
InChI	1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
InChIKey	DGVVWUTYPXICAM-UHFFFAOYSA-N
SMILES	OCCS
LogP	-0.20
CAS DataBase Reference	60-24-2(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2-mercapto-(60-24-2)
EPA Substance Registry System	60-24-2(EPA Substance)
Absorption	≤0.31 at 280nm ≤1.50 at 260nm

Safety Data

Symbol(GHS)	GHS05,GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H301+H331-H310-H315-H317-H318-H361d-H373-H410
Precautionary statements	P273-P280-P301+P310-P302+P352+P310-P304+P340+P311-P305+P351+P338
Hazard Codes	T,N
Risk Statements	R20/22:Harmful by inhalation and if swallowed . R24:Toxic in contact with skin. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed. R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S61:Avoid release to the environment. Refer to special instructions safety data sheet . S29:Do not empty into drains . S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . S27:Take off immediately all contaminated clothing . less more
RIDADR	UN 2966 6.1/PG 2
WGK Germany	3
RTECS	KL5600000
F	3-10-13-23
Autoignition Temperature	295 °C
TSCA	Yes
REACH Registrations	Active
HazardClass	6.1
PackingGroup	II
HS Code	29309070
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 2 Eye Dam. 1 Repr. 2 Skin Irrit. 2 Skin Sens. 1A STOT RE 2 Oral
Safety Profile	Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by intravenous route. A skin and severe eye irritant. Human mutation data reported. A combustible liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of SOx. See also MERCAPTANS. less more
Hazardous Substances Data	60-24-2(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description

A water-white liquid. May be toxic by ingestion, inhalation, or skin absorption.

Reactivity Profile

Organosulfides, such as THIOGLYCOL(60-24-2), are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Air & Water Reactions

No rapid reaction with air. No rapid reaction with water.

Hazard

Toxic by inhalation and ingestion.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Chemical Properties

Clear colorless liquid. 2-mercaptoethanol (bME) is a popular effective reducer, but extremely pungent.

Uses

2-Mercaptoethanol is used in the synthesis of nano-graphene for cellular imaging and drug delivery. Also used in the synthesis of multifunctional polymeric micelle used in specific targeting of tumor disruption.

Uses

Solubilizes proteins by reducing disulfide linkages2-Mercaptoethanol is used in the preparation of nano-graphene for cellular imaging and drug delivery as well as multifunctional polymeric micelle. It acts as a reducing agent used in electrophoresis, amino acid detection, and distinguishing ssDNA/dsDNA. It is also employed as a standard buffer. It is also used in the preparation of PVC heat stabilizers and as a chain transfer agent in the manufacture of PVC. Further, it is used in some RNA isolation procedures to eliminate ribonuclease. It is utilized as a corrosion inhibitor and ore floatation agent. In biochemistry, it is useful to study the activity of the immune system.

Application

Definition

ChEBI: 2-Mercaptoethanol is a primary alcohol and an alkanethiol. It has a role as a geroprotector.

reaction suitability

reagent type: reductant

Purification Methods

Purify it by distilling in a vacuum. Distilling at atmospheric pressure causes some oxidation and should be done in an inert atmosphere. [Woodward J Chem Soc 1892 1948.] It has a foul odour, is irritating t o the eyes, nose and skin — should be handled in an efficient fume cupboard. It is miscible with H2O, EtOH, Et2O and *C6H6 and the UV has max at 235nm. The 2,4-dinitrophenyl thioether has m 101-102o (from EtOH or aqueous MeOH) [Grogen et al. J Org Chem 20 50 1955]. [Beilstein 1 IV 2428.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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