ChemicalBook CAS DataBase List 27833-64-3

27833-64-3

Name	Loxapine succinate salt
CAS	27833-64-3
EINECS(EC#)	248-682-0
Molecular Formula	C22H24ClN3O5
MDL Number	MFCD00069298
Molecular Weight	445.9
MOL File	27833-64-3.mol

Chemical Properties

Appearance	White to Of-White Solid
Melting point	150-152°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H₂O: soluble
form	solid
color	white
Usage	A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent
CAS DataBase Reference	27833-64-3(CAS DataBase Reference)

Safety Data

RIDADR	UN 2811 6.1 / PGII
WGK Germany	3
RTECS	WM5750000
HS Code	29329990

Hazard Information

Description

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α₁-adrenergic receptors (K_i values are 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.

Description

Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.

Chemical Properties

White to Of-White Solid

Uses

A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent

Uses

choleretic

Uses

Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.

Brand name

Loxapine (Mylan); Loxitane (Watson).

Toxicity evaluation

Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.

Spectrum Detail

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