22280-60-0

Light yellow Cryst

6-Chloro-2-methyl-3-nitropyridine has been used as a reactant for the synthesis of fluorine-containing pyridinealdoxime derivatives as treatment of organophosphorus nerve-agent poisoning.

A mixture of 2-oxo-5-nitro-6-methyl-1,2-dihydropyridine, phosphorous oxychloride, and phosphorous pentachloride was heated at 110° C for 2 hours, whereupon the reaction mixture was charged with an additional portion of phosphorous pentachloride and phosphorous oxychloride. The reaction was stirred for 1 hour and then poured into ice water. The brown solid was filtered and washed with cold water, to give 6-Chloro-2-methyl-3-nitropyridine (94%).