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108-48-5

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Identification

Name
2,6-Lutidine
CAS
108-48-5
Synonyms
2,6-DIMETHYLPYRIDINE
26L
2,6-LUTIDINE
DIMETHYLPYRIDINE(2,6-)
FEMA 3540
FEMA NUMBER 3540
2,6-dimethyl-pyridin
2,6-Dimethypyridine
2,6-Lutidene
alpha,alpha’-dimethylpyridine
alpha,alpha’-lutidin
alpha,alpha’-lutidine
alpha,alpha'-Dimethylpyridine
alpha,alpha'-Lutidin
alpha,alpha'-Lutidine
Pyridine,2,6-dimethyl-
2,6-Lutidine 2,6-Dimethylpyridine
2 6-DIMETHYLPYRIDINE 99+%
2,6-LUTIDINE, REDISTILLED, 99+%
2 6-LUTIDINE REAGENTPLUS(TM) 99%
EINECS(EC#)
203-587-3
Molecular Formula
C7H9N
MDL Number
MFCD00006345
Molecular Weight
107.15
MOL File
108-48-5.mol

Chemical Properties

Appearance
Colorless to yellow liquid
mp 
-6 °C
bp 
143-145 °C(lit.)

density 
0.92 g/mL at 25 °C(lit.)

FEMA 
3540
refractive index 
n20/D 1.497(lit.)

Fp 
92 °F

storage temp. 
−20°C

Stability:
Stable. Flammable. Incompatible with strong oxidizing agents, acid chlorides, acids, chloroformates. Protect from moisture.
Water Solubility 
40 g/100 mL (20 ºC)
Merck 
14,5616
Detection Methods
GC,NMR
BRN 
105690
CAS DataBase Reference
108-48-5(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,6-dimethyl-(108-48-5)
EPA Substance Registry System
108-48-5(EPA Substance)

Safety Data

Hazard Codes 
Xn,F,Xi
Risk Statements 
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
RIDADR 
UN 1993 3/PG 3

WGK Germany 
3

RTECS 
OK9700000


8
Hazard Note 
Irritant/Flammable
HazardClass 
3
PackingGroup 
III
HS Code 
29333999
Hazardous Substances Data
108-48-5(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A colorless liquid with a peppermint odor. Flash point 92°F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.
Reactivity Profile
LUTIDENE(108-48-5) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Highly flammable. Soluble in water.
Health Hazard
Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Material Safety Data Sheet(MSDS)

Questions And Answer

Chemical Properties
Colorless oily liquid, melting point-5.8℃, boiling point 144℃(139-141℃,145.6-145.8℃), density 0.9252(20/4℃), refractive index 1.4977, flash point 33℃, soluble in dimethyl formamide, tetrahydrofuran, cold water, hot water, ethanol and ether, with mixed odor of Pyridine and mint.
Usage
2,6-Lutidine is widely used in organic synthesis as a raw material and solvent. In Pharmaceutical industry, it can be used for the production of antiatherosclerotic pyridinolcarbamate. It can also be used for the production of Cortisone acetate, hydrocortisone, niacin, lobeline and stilbazium iodide which is an anthelmintic and effective for the worm, fasciolopsis buski, whipworm, pinworm and so on. In addition, 2,6-Lutidine can be used as an auxiliaries for Pesticides, dyes, dyeing and printing and used as resin and rubber accelerator,  intermediate of hot oil stabilizer.  It  can be oxidized to produce Dimethyl pyridine acid, which can be used as the stabilizer for hydrogen peroxide and acetic acid and used to synthesize lobelidine. 2,6-Lutidine is used as various kinds of nutty essence and cocoa, coffee, meat, bread and vegetable typed essence. It is also used to synthesize drugs for the treatment and first-aid of hypertension.
Preparation
2,6-Lutidine is obtained through the separation of β-methylpyridine which is a recycled product of coal coking byproduct.
Category
flammable liquid
Toxicity grade
high toxic
Acute toxicity
oral – rat LD50: 400mg/kg
Flammability hazard characteristics
flammable in case of fire, high temperature and oxidant, releasing toxic nitrogen oxides in case of heat.
Storage
Ventilated and dry warehouse with low temperature, separated from acids.
Fire extinguishing agents
Dry powder, dry sand, carbon dioxide, foam.

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