13965-03-2

Bis(triphenylphosphine)palladium chloride(13965-03-2) is a coordination compound of palladium containing two triphenylphosphine and two chloride ligands. This yellow solid is insoluble in water but can dissolve in some organic solvents, such as toluene and benzene, and is slightly soluble in acetone and chloroform. It is used for palladium-catalyzed coupling reactions, e.g. the Sonogashira–Hagihara reaction. The complex adopts a square planar geometry and numerous similar complexes are known, with different phosphine ligands.

Bis(triphenylphosphine)palladium(II) chloride is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of me tallacyclic complexes which show antiinflammatory and antifungal properties.

Bis(triphenylphosphine)palladium(II) chloride may be prepared by treating palladium(II) chloride with triphenylphosphine:
PdCl2 + 2 PPh3 → PdCl2(PPh3)2

Bis(triphenylphosphine)palladium(II) chloride may be synthesized by treating palladium(II) chloride with triphenylphosphine:
PdCl2 + 2 PPh3 → PdCl2(PPh3)2

Precatalyst for the carbonylative cyclization of malonate derivatives.
Catalyst used in the double allylation of activated olefins.
Precatalyst for the three-component preparation of 3-arylidene- (or 3-alkenylidene) tetrahydrofurans.
Precatalyst for the homocoupling of terminal alkynes.
Precatalyst in the cross-coupling of alkynylsilanols and aryl halides.
Catalyst for direct Pd-catalyzed alkynylation of N-fused heterocycles.
Catalyst for a tandem Heck reaction/C-H functionalization.
Catalyst for direct arylation of tautomerizable heterocycles.

Nonflammable

reagent type: catalyst
reaction type: Cross Couplings