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Raw materials And Preparation Products

Hazard Information

Chemical Properties

dark yellow powder

Physical properties

Bis(acetonitrile)dichloropalladium(II) is a yellow-brown solid that is soluble in organic solvents. It is a reagent and a catalyst for reactions that require soluble Pd(II).The compound is similar to bis(benzonitrile)palladium dichloride. 

Uses

suzuki reaction

Application

Synthesis of Oxindoles

To a dried screw-cap vial is added anilide (0.3 mmol), AgOCOCF3 (132.5 mg, 0.6 mmol), Bis(acetonitrile)dichloropalladium(II) (3.5 mg, 0.015 mmol) and chlorobenzene. The reaction mixture is stirred at 100-120 °C for 3-12 h in a pre-heated oil bath. After cooling to room temperature, the reaction is diluted with EtOAc and filtered with a glass filter. The filtrate is washed with 5% aqueous NaHCO3 and brine. The extract is dried over MgSO4 and concentrated in vacuo. The crude is purified by preparative TLC.

Preparation

Bis(acetonitrile)palladium dichloride is prepared by reacting two acetonitrile ligands and palladium(II) chloride.

General Description

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reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst

Material Safety Data Sheet(MSDS)

Questions And Answer

• Reaction

  1. Catalyst for the cyclization of δ-acetylenic carboxylic acids to butenolides.
  2. Catalyst for the aza-Michael reaction of carbamates with enones.
  3. Catalyst for the rearrangement of allylic imidates to allylic amides.
  4. Catalyst for the Nazarov cyclization of α-alkoxy dienones.
  5. Catalyst for the diamination of conjugated dienes.
  6. Three component Michael addition, cyclization, cross-coupling reaction.
  7. C-H activation of indoles.
  8. Catalyst used for the direct C-H arylation of isoxazoles at the 5 position.
  
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Spectrum Detail

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