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Tan Solid

Acaricide.

Tebufenpyrad is a pyrazole acaricide and insecticide commonly used in commercial greenhouses.

ChEBI: Tebufenpyrad is a pyrazole acaricide and a pyrazole insecticide. It has a role as a mitochondrial NADH:ubiquinone reductase inhibitor.

Tebufenpyrad is produced commercially through a multi-step organic synthesis that constructs its pyrazole-based structure. The process begins with the preparation of key intermediates such as substituted benzyl halides and pyrazole derivatives. These are reacted under controlled conditions to form the core tebufenpyrad molecule, which includes a tert-butyl group and a phenyl ring that enhance its lipophilicity and biological activity.

Mitochondrial complex I electron transport inhibitor, non-systemic with contact and stomach action

By incubation of tebufenpyrad with rat liver homogenate, tebufenpyrad undergoes biotransformation to yield the major metabolites N-(4- tert-butylbenzyl)-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide via hydroxylation of the w-1-carbon of the ethyl group and N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-ethyl-1-methylpyrazole- 5-carboxamide via oxidation of the methyl group in the tert-butyl moiety to the carboxylic acid derivatives.
When the rat is orally dosed tebufenpyrad, the major metabolism pathway is via both hydroxylation and oxidation reactions to yield N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide which is mainly excreted in the urine.

Acaricide; Insecticide