ChemicalBook CAS DataBase List 1166-52-5

1166-52-5

Name	Dodecyl gallate
CAS	1166-52-5
EINECS(EC#)	214-620-6
Molecular Formula	C19H30O5
MDL Number	MFCD00002195
Molecular Weight	338.44
MOL File	1166-52-5.mol

Synonyms

3,4,5-TRIHYDROXYBENZOIC ACID DODECYL ESTER DODECYL 3,4,5-TRIHYDROXYBENZOATE DODECYL GALLATE GALLIC ACID DODECYL ESTER GALLIC ACID LAURYL ESTER GALLIC ACID N-DODECYL ESTER LAURYL GALLATE N-DODECYL GALLATE 3,4,5-trihydroxy-benzoicacidodecylester Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester Benzoicacid,3,4,5-trihydroxy-,dodecylester dodecyl3,4,5- Dodecylester kyseliny gallove dodecylesterkyselinygallove Lauryl 3,4,5-trihydroxybenzoate Nipagallin LA nipagallinla Progallin LA progallinla n-dodecyl 3,4,5-trihydroxybenzoate

Chemical Properties

Appearance	white to cream powder
Melting point	94-97 °C(lit.)
Boiling point	394.57°C (rough estimate)
density	1.0677 (rough estimate)
refractive index	1.6120 (estimate)
storage temp.	0-6°C
solubility	Very slightly soluble or practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form	neat
pka	7.93±0.25(Predicted)
color	White to Almost white
Odor	at 100.00?%. odorless
Water Solubility	practically insoluble
Sensitive	Air Sensitive
BRN	2701981
Major Application	cleaning products cosmetics food and beverages personal care
Cosmetics Ingredients Functions	ANTIOXIDANT
InChI	1S/C19H30O5/c1-2-3-4-5-6-7-8-9-10-11-12-24-19(23)15-13-16(20)18(22)17(21)14-15/h13-14,20-22H,2-12H2,1H3
Contact allergens	This gallic acid ester (E 310) is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were reported in workers of the food industry, gallate being contained in margarine, and from washing powder. less more
InChIKey	RPWFJAMTCNSJKK-UHFFFAOYSA-N
SMILES	CCCCCCCCCCCCOC(=O)c1cc(O)c(O)c(O)c1
LogP	6.365 (est)
Uses	Antioxidant. less more
CAS DataBase Reference	1166-52-5(CAS DataBase Reference)
NIST Chemistry Reference	Gallic acid, n-dodecyl ester(1166-52-5)
EPA Substance Registry System	1166-52-5(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
Hazard Codes	Xi
Risk Statements	R43:May cause sensitization by skin contact. less more
Safety Statements	S24:Avoid contact with skin . S37:Wear suitable gloves . less more
RIDADR	3335
WGK Germany	1
RTECS	DH9100000
TSCA	Yes
HS Code	29182950
Storage Class	13 - Non Combustible Solids
Hazard Classifications	Skin Sens. 1
Safety Profile	Poison by ingestion and inhalation. Moderately toxic by skin contact. A severe eye irritant. Questionable carcinogen with experimental tumorigenic data. A pesticide. When heated to decomposition it emits very toxic fumes of NOx. less more
Toxicity	LD50 orally in Rabbit: 5000 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

white to cream powder

Description

This gallate ester (E 310) is an antioxidant added to foods and cosmetics to prevent oxidation of unsaturated fatty acids. Cases have been reported in workers in the food industry, gallate being contained in margarine. It is also present in washing powder.

Definition

ChEBI: Dodecyl gallate is a gallate ester.

General Description

Lauryl gallate is a major monomer flavanol found in green tea and shows antioxidant activity in polymers.

Biological Activity

Dodecyl gallate exhibits both potent chain-breaking and preventive antioxidant activity. The pyrogallol moiety is responsible for both activities. Dodecyl (lauryl) gallate prevents generation of superoxide radicals by xanthine oxidase, and this activity comes from its ability to inhibit the enzyme^[1].

Carcinogenicity

In a 2-year feeding study, with the administration of up to 5 mg/kg of feed to rats, no increase in tumor incidence was noted . In female mice, a dermal injection of dodecyl gallate (100 nmol in 0.2mL acetone) inhibits the formation of skin carcinomas and papillomas induced by the tumor promoter phorbol myristate and the initiator 7,12-dimethylbenz[a]anthracene .

storage

Store at -20°C

References

[1] Kubo, I., Masuoka, N., Xiao, P., Haraguchi, H. (2002). Antioxidant Activity of Dodecyl Gallate. Journal of Agricultural and Food Chemistry, 50 12, 3533–3539. https://doi.org/10.1021/jf011250h

Material Safety Data Sheet(MSDS)

Spectrum Detail

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