Description
Dilauryl thiodipropionate (DLTDP) is a part synthetic, part plant-derived ester blend made from the fatty alcohol lauryl alcohol and the antioxidant thiodipropionic acid. Not surprisingly, it has antioxidant benefits on the skin and, according to older research from Avon, may play a role in fading the appearance of discolourations. It also works in cosmetics as a sequestering agent, which helps keep ingredients in a formula from having unwanted interactions. As such, it also helps stabilize cosmetics. DLTDP is a secondary artificial antioxidant widely used to extend the shelf life of products in the food, cosmetic, and polymer industries. Furthermore, some studies on asphalt antioxidants warned about the softening effect of DLTDP on asphalt binders, even after ageing. DLTDP has been declared by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) for use in food and cosmetics, which implies its safe use when used as intended and under specific limitations (based mainly on fat content)[1].
Chemical Properties
White flaky crystalline solid. Insoluble in water, soluble in organic solvents such as acetone, carbon tetrachloride, benzene, and petroleum ether. Solubility in various solvents (g/100g solvent) at 20°C is: acetone 20; carbon tetrachloride 100; benzene 133; petroleum ether 40.
Definition
ChEBI: Didodecyl thiobispropanoate is a dicarboxylic acid.
Flammability and Explosibility
Nonflammable
Toxicology
According to the classification scheme of Hodge and Sterner, thiodipropionic acid (TDPA) and Dilauryl thiodipropionate (DLTDP) were slightly toxic when administered to mice and rats by the oral route. TDPA, when administered intraperitoneally, was moderately toxic to rats, while DLTDP was slightly toxic. TDPA was moderately toxic when administered intravenously to mice. TDPA and DLTDP were considered relatively nontoxic in subchronic oral toxicity studies with rats. No specific treatment-related effects were noted when TDPA was administered in the drinking water to guinea pigs for 4 months. No irritation was produced by a makeup foundation containing 0.05% DLTDP when tested at 0.0025% on intact and abraded skin of New Zealand white rabbits. Neither TDPA nor DLTDP produced signs of irritation when applied to the shaved skin of rabbits for 24 hours. In a guinea pig maximisation test, a makeup foundation containing 0.05% DLTDP was not a sensitizer. TDPA was tested for sensitization potential in guinea pigs, and though there were signs of local irritation at the injection sites, the TDPA was not considered a sensitizer. DLTDP was not phototoxic to New Zealand white rabbits at a concentration of 0.05% in a makeup foundation. No signs of irritation were observed when a solution containing TDPA was placed into the conjunctival sacs of rabbits. TDPA was neither a teratogen nor a reproductive toxicant when administered orally to mice, rats, hamsters, or rabbits during gestation.
References
[1] I. Camargo. “Dilauryl thiodipropionate as a regeneration agent for reclaimed asphalts.” Construction and Building Materials (2023).
