2-хлорацетофенон
- английское имя2-Chloroacetophenone
- CAS №532-27-4
- CBNumberCB9387386
- ФормулаC8H7ClO
- мольный вес154.59
- EINECS208-531-1
- номер MDLMFCD00000933
- файл Mol532-27-4.mol
химическое свойство
| Температура плавления | 54-56 °C(lit.) |
| Температура кипения | 244-245 °C(lit.) |
| плотность | 1.324 g/mL at 25 °C(lit.) |
| давление пара | 4 at 20 °C, 14 at 30 °C (quoted, Verschueren, 1983) |
| показатель преломления | 1.5438 |
| Fp | 118°C |
| растворимость | Soluble in acetone (Weast, 1986). Freely soluble in alcohol, benzene, and ether (Windholz et al., 1983) |
| форма | Colorless crystals |
| Растворимость в воде | insoluble. <0.1 g/100 mL at 19 ºC |
| Чувствительный | Moisture Sensitive |
| Мерк | 14,2115 |
| БРН | 507950 |
| Пределы воздействия | NIOSH REL: TWA 0.3 mg/m3 (0.05 ppm), IDLH 15 mg/m3; OSHA PEL: TWA 0.05 ppm (0.3 mg/m3); ACGIH TLV: TWA 0.05 ppm (adopted). |
| Стабильность | May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols. |
| ИнЧИКей | IMACFCSSMIZSPP-UHFFFAOYSA-N |
| LogP | 1.724 (est) |
| Справочник по базе данных CAS | 532-27-4(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 88B5039IQG |
| Справочник по химии NIST | Ethanone, 2-chloro-1-phenyl-(532-27-4) |
| Система регистрации веществ EPA | 2-Chloroacetophenone (532-27-4) |
больше
| Коды опасности | T | |||||||||
| Заявления о рисках | 25-36/37/38-42/43-23/25-36-23/24/25 | |||||||||
| Заявления о безопасности | 22-26-36/37/39-45-28A-7/9 | |||||||||
| РИДАДР | UN 1693 6.1/PG 2 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.3 mg/m3 (0.05 ppm) | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | AM6300000 | |||||||||
| F | 9-19 | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 6.1 | |||||||||
| Группа упаковки | II | |||||||||
| Банк данных об опасных веществах | 532-27-4(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in rats (mg/kg): 41 i.v., 36 i.p., 127 orally; LC50 in rats: 8750 mg/min/m3 (Ballantyne, Swanston) | |||||||||
| ИДЛА | 15 mg/m3 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H335：Может вызывать раздражение верхних дыхательных путей.
H318：При попадании в глаза вызывает необратимые последствия.
H300：Смертельно при проглатывании.
H334：При вдыхании может вызывать аллергическую реакцию (астму или затрудненное дыхание).
H311+H331：Токсично при попадании на кожу или при вдыхании.
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оператор предупредительных мер
P261：Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P310：ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P302+P352+P312：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Обратиться за медицинской помощью при плохом самочувствии.
P304+P340+P311：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
2-хлорацетофенон химические свойства, назначение, производство
Описание
Chloroacetophenone is contained in tear gases (lacrimators). This substance has an important irritative potential but can also be a sensitizer.Химические свойства
2-Chloroacetophenone (CN) is a combustible, colorless-to-gray solid. CN has a sharp, irritating odor, has been described as smelling like “apple blossoms.” It may be dissolved in a solventФизические свойства
Colorless to gray crystalline solid with a sharp, penetrating, irritating odor. The low odor and high odor threshold concentrations were 102 and 150 μg/m3, respectively (Ruth, 1986).Использование
Riot control agent.Определение
A strong lachrymator.Общее описание
2-chloroacetophenone appears as a white crystalline solid. Denser than water and insoluble in water. Hence sinks in water. A lachrymator: vapors are very irritating to the eyes. Has a floral odor. Used as a riot control agent.Опасность
The main uses for 2-chloroacetophenone are in tear gas and in chemical Mace. It is a potent eye, throat, and skin irritant. Acute (short-term) inhalation exposure of humans causes burning of the eyes with lacrimation, some degree of blurred vision, possible corneal damage, irritation and burning of the nose, throat, and skin, and burning in the chest with dyspnea. Acute dermal exposure is irritating and can result in first, second, and third degree chemical burns in humans. Squamous hyperplasia of the nasal respiratory epithelium was reported in rats chronically exposed (long-term) via inhalation. EPA has not classified 2-chloroacetophenone with respect to potential carcinogenicity.Угроза здоровью
Median lethal dose (mg-min/m3): 11000 (estimated). Median incapacitating dose: 80. Eye/skin toxicity: Temporarily severe eye irritation; mild skin irritation. Rate of action: Instantaneous. Physiological action: Powerfully lacrimatory. Detoxification rate: Rapid. (ANSER)Пожароопасность
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.Контактные аллергены
w-Chloroacetophenone is contained in tear gases (lacrimators). This substance has important irritative potential, but can also be a sensitizer.Профиль безопасности
A human poison by inhalation. An experimental poison by ingestion, inhalation, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, and unspecified eye effects, cough, and dyspnea. A severe eye and moderate skin irritant. Questionable carcinogen with experimental neoplastigenic data by skin contact. A riot control agent. When heated to decomposition it emits toxic fumes of Cl-. See also KETONES.Возможный контакт
Chloroacetophenone is used as a chemical warfare agent (Agent CN) and as a principal ingredient in the riot control agent Mace. It is also used as a pharmaceutical intermediate. The United States considers agent CN and its mixtures with various chemicals to be obsolete for military deployment.Экологическая судьба
Chemical/Physical. Releases toxic chloride fumes when heated to decomposition (Sax and Lewis, 1987).Перевозки
UN1697 Chloroacetophenone, solid, (CN), Hazard Class: 6.1; Labels: 6.1-Poison Inhalation. UN3416 Chloroacetophenone, liquid, (CN), Hazard Class: 6.1;Labels: 6.1-Poisonous materials. Hazard. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.Методы очистки
Crystallise it from MeOH [Tanner J Org Chem 52 2142 1987]. [Beilstein 7 IV 641.]Несовместимости
Keep away from water, steam, strong oxidizers. CN reacts with water, forming hydrochloric acid. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. CN reacts slowly with metals, causing mild corrosion and may evolve flammable hydrogen gas.Утилизация отходов
Tear gas-containing waste is dissolved in an organic solvent and sprayed into an incinerator equipped with an afterburner and alkaline scrubber utilizing reaction with sodium sulfide in an alcoholwater solution. Hydrogen sulfide is liberated and collected by an alkaline scrubber.2-хлорацетофенон запасные части и сырье
2-хлорацетофенон поставщик
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2-хлорацетофенон Обзор)
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