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Рисперидон
- английское имяRisperidone
- CAS №106266-06-2
- CBNumberCB9131730
- ФормулаC23H27FN4O2
- мольный вес410.48
- EINECS600-733-1
- номер MDLMFCD00274576
- файл Mol106266-06-2.mol
химическое свойство
Температура плавления | 170°C |
Температура кипения | 572.4±60.0 °C(Predicted) |
плотность | 1.38±0.1 g/cm3(Predicted) |
Fp | 9℃ |
температура хранения | 2-8°C |
растворимость | DMSO: ≥5mg/mL |
пка | pKa 8.3 (Uncertain) |
форма | powder |
цвет | white to off-white |
Растворимость в воде | 44.74mg/L(25 ºC) |
Мерк | 14,8233 |
BCS Class | 2 |
Справочник по базе данных CAS | 106266-06-2(CAS DataBase Reference) |
Словарь онкологических терминов NCI | Risperdal; risperidone |
FDA UNII | L6UH7ZF8HC |
Код УВД | N05AX08 |
Коды опасности | T,F | |||||||||
Заявления о рисках | 25-39/23/24/25-23/24/25-11 | |||||||||
Заявления о безопасности | 28-36-45-36/37-16 | |||||||||
РИДАДР | 3249 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | UV1164800 | |||||||||
Класс опасности | 6.1(a) | |||||||||
Группа упаковки | II | |||||||||
кода HS | 29333990 | |||||||||
Банк данных об опасных веществах | 106266-06-2(Hazardous Substances Data) | |||||||||
Токсичность | LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301:Токсично при проглатывании.
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оператор предупредительных мер
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
Рисперидон химические свойства, назначение, производство
Описание
Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonist activity. While the anti-D2 activity may relate to the antipsychotic potency of neuroleptic agents, an antidepressive efficacy of substances with anti-5-HT2 activity has been suggested. Risperidone, therefore, has therapeutic action on both positive and negative symptoms of schizophrenia and produces significantly fewer side effects especially extrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics. It also has potential for management of alcohol withdrawal and cocaine addiction.Химические свойства
Crystalline SolidИспользование
Risperidone has been used:- to study its effects on bone formation and differentiation
- to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
- to reverse induced schizophrenia-like behavior in mice
Определение
ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.Общее описание
Risperidone (Risperdal, a benzisoxazole)has the structural features of a hybrid molecule between abutyrophenone antipsychotic and a trazodone-like antidepressant.Its superior side effects profile (compared withhaloperidol) at dosage of 6 mg/d or less and the lower riskof tardive dyskinesia have contributed to its very widespreaduse. It benefited refractory psychotic patients, withparkinsonism controlled at one tenth the dose of antiparkinsoniandrugs used with haloperidol.Coexisting anxietyand depressive syndromes were also lessened. It is reportedto decrease the negative (e.g., withdrawal, apathy) as well asthe positive (e.g., delusions, hallucinations) symptoms ofschizophrenia. This is reportedly a consequence of the compound’scombination 5-HT2–D2 receptor antagonistic properties.Overall, the reasons for the decreased EPS and effectiveness against negative symptom are still under investigation.It is an important atypical antipsychotic.Risperidone is metabolized in the liver by CYP2D6 to anactive metabolite, 9-hydroxyrisperidone. Because thismetabolite and risperidone are nearly equipotent, the clinicalefficacy of the drug reflects both compounds.Биологическая активность
Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).Рисперидон запасные части и сырье
сырьё
- Рисперидал iMpurity B
- 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
- 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
- 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one
- Рисперидон Э-Оксим
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