Дифеноксилат
- английское имяDiphenoxylate
- CAS №915-30-0
- CBNumberCB3301641
- ФормулаC30H32N2O2
- мольный вес452.59
- EINECS213-020-1
- номер MDLMFCD00072110
- файл Mol915-30-0.mol
химическое свойство
| Температура кипения | 602.3±55.0 °C(Predicted) |
| плотность | 1.123±0.06 g/cm3(Predicted) |
| пка | pKa 7.1 (Uncertain) |
| Справочник по базе данных CAS | 915-30-0(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 73312P173G |
| Код УВД | A07DA01 |
| Справочник по химии NIST | Diphenoxylate(915-30-0) |
| Коды опасности | T+ |
| Заявления о рисках | 26/27/28-42/43 |
| Заявления о безопасности | 22-26-45 |
| Банк данных об опасных веществах | 915-30-0(Hazardous Substances Data) |
| Токсичность | Diphenoxylate is an antiperistaltic, antidiarrheal drug that is also listed as a controlled substance (opiate). |
Дифеноксилат химические свойства, назначение, производство
Использование
Antiperistaltic.Определение
ChEBI: A piperidinecarboxylate ester that is the ethyl ester of difenoxin.Показания
Diphenoxylate (marketed in combination with atropine as Lomotil in the United States) is chemically related to both analgesic and anticholinergic compounds. It is as effective in the treatment of diarrhea as the opium derivatives, and at the doses usually employed, it has a low incidence of central opioid actions. Diphenoxylate is rapidly metabolized by ester hydrolysis to the biologically active metabolite difenoxylic acid.Всемирная организация здравоохранения(ВОЗ)
Diphenoxylate, a derivative of pethidine without analgesic activity, is used in the symptomatic treatment of acute and chronic diarrhoea to reduce intestinal motility. There is no clear evidence that it has any beneficial effect in diminishing fluid losses and it has been associated with central nervous system toxicity, particularly in children, which results in anorexia, nausea and vomiting, headache, drowsiness, confusion, insomnia, dizziness, restlessness, euphoria and depression. The World Health Organization recommends that diphenoxylate should not be used for the management of diarrhoea in children and many countries have since withdrawn products containing this compound indicated for paediatric use. (Reference: (WHORUD) The Rational Use of Drugs, , , 1990)Общее описание
Diphenoxylate is a weak opioid agonist and isavailable combined with atropine (Lomotil) for use as an antidiarrhealagent. At low doses, the opioid effect is minimal,and the atropine is added to dissuade abuse. One studyfound both codeine and loperamide to be superior to diphenoxylatefor treating chronic diarrhea.83 The manufacturerhas strict dosing guidelines for pediatric use because opioidintoxication and deaths from diphenoxylate have beenreported.Клиническое использование
Lomotil is recommended as adjunctive therapy in the management of diarrhea. It is contraindicated in children under 2 years old and in patients with obstructive jaundice.Побочные эффекты
Adverse reactions often caused by the atropine in the preparation include anorexia, nausea, pruritus, dizziness, and numbness of the extremities.