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• Risperidone manual

  Characters: 1mg Risperidone tablets are white film-coated tablets, after removing the coating ,they are white; 2mg Risperidone tablets are pale orange film-coated tablets,after removing the coating , they are white.
  Pharmacological characteristics: This product is benzisoxazole derivative,it is a new generation of antipsychotics. Its active ingredient Risperidone  is a selective monoamine antagonist with unique properties, it has a high affinity with the serotonin 5-HT2 receptors and the dopamine D2 receptors . Risperidone can also be combined with α1-adrenergic receptors  , and it can combine with the histamine H1-receptors and α2-adrenoceptors  with lower affinity . Risperidone can not combine with cholinergic receptors. Risperidone is a potent D2 antagonist, which can improve the positive symptoms of schizophrenia, but inhibition of motor function, as well as  catalepsy caused by it are lesser than classical antipsychotics. Balance of serotonin and dopamine antagonism of the central nervous systemcan can reduce the potential for extrapyramidal side effects, and  expand its role in the treatment of negative symptoms and affective symptoms of schizophrenia.
  Pharmacokinetic characteristics: after oral administration,Risperidone can be completely absorbed and the peak of plasma concentration is reached within 1-2 hours, and its absorption is not affected by food. In vivo, Risperidone is metabolized to 9-hydroxy portion-Risperidone, which has similar pharmacological effects to Risperidone. This product can be quickly distributed in the body, Risperidone plasma protein binding rate is 88%, 9-hydroxy-Risperidone plasma protein binding rate is 77%. The drug elimination half-life is about three hours, antipsychotic active ingredient elimination half-life is 24 hours. Most patients reach a steady state of Risperidone in a day, and after 4-5 days ,they reach the 9-hydroxy-risperidone homeostasis. One week after treatment, 70% of the drug  is excreted in urine and 14% of the drug is through fecal excretion, 35-45% of the section of urinary excretion are Risperidone and 9-hydroxy-risperidone, the remaining is non-active metabolite . Elderly patients and patients with renal insufficiency have higher plasma concentrations of Risperidone, so they have slower clearance.;

• Chemical Properties

  It is obtained from dimethylformamide-isopropyl crystallization, m.p. 170.0 ℃. Acute toxicity LD50 male and female mice, male and female rats, male and female dogs (mg/kg): 29.7,26.9,34.3,35.4,14.1,18.3 intravenous injection; 82.1,63.1,113,56.6,18.3,18.3 oral.;

• Uses

  1. It has antagonism effect on 5HT2 receptors and D2 receptors. It is used for acute and chronic schizophrenia.
  2. Antipsychotic drugs.;

• Benefits and side effects

  Risperidone advantages:
  (1)it is effective not only for positive symptoms, but also  effective for negative symptoms, it can also improve cognitive disorders, thereby improving the patient's condition as a whole.
  (2) adverse reactions of the drug is light,it  produces fewer extrapyramidal side effects.
  (3)it is easy to adjust the dose, for most patients, the dose is 2~6mg/d, which can produce a therapeutic effect.
  (4) for some poor therapeutic effect of conventional antipsychotics or intolerant patients, Risperidone may produce better results.
  (5)Compliance of patients  greatly increases during the period of medication .
  (6) foreign research shows, Risperidone  can reduce the expenses of patients and reduce the overall expenditure of the patients, and thus more in line with the principles of health economics.
  Risperidone side effects:
  Risperidone common adverse reactions: insomnia, anxiety, agitation, headache; rare adverse reactions are: drowsiness, fatigue, dizziness, decreased attention, constipation, indigestion, nausea, vomiting, abdominal pain, blurred vision, priapism, erectile dysfunction, weak ejaculation, sexual apathy, urinary incontinence, rhinitis, rash and other allergic reactions. Risperidone can cause extrapyramidal side effects, tremors, rigidity, salivation, bradykinesia, akathisia, acute dystonia, orthostatic hypotensionlactation,lactation, gynecomastia, menstrual disorders, amenorrhea can occur occasionally, Risperidone can also cause weight gain, edema, and increased liver enzymes and so on.;

• Effect

  It is used for the treatment of acute and chronic schizophrenia and other various psychotic state  obvious positive symptoms (such as hallucinations, illusions, thought disorder, hostility, suspicion) and significant negative symptoms (such as unresponsiveness, emotional apathy and social apathy, of few words). Also it can alleviate affective symptoms associated with schizophrenia (such as: depression, guilt, anxiety).  For  patients whom  Risperidone is effective to for acute treatment ,in the maintenance phase of treatment, the Risperidone can continue to play its clinical efficacy.;

• medicine interactions

  1. It can antagonize levodopa and other dopamine agonists role.
  2. carbamazepine and other hepatic enzyme inducers may reduce the plasma concentration of the active ingredient of the product, once stop using carbamazepine or other hepatic enzyme inducers, the product should be re-determined its dose ,reduction if necessary .
  3. phenothiazines, tricyclic antidepressants, and some β-blockers may increase the plasma concentration of this product, but they do not increase the plasma concentration of the antipsychotic active ingredient.
  4. When taken together with other highly protein bound drugs , there is no clinically significant mutual replacement of plasma protein.;

• production method

  1-Acetyl-4-methyl-piperidine chloride and difluorobenzene react under aluminum trichloride catalysis, after acylation, use hydrochloric acid hydrolysis to deacetylate in piperidine ring, and then after hydroxylamine ,use base to catalyze, after cyclization , get benzisoxazole derivatives. 4.4 parts of the isoxazole derivatives, 5.3 parts of ethyl 3-chloro-2-methyl-4H-pyrido [1,2-α] pyrimidin-4-one hydrochloride, 8 parts of sodium carbonate and 0.1 parts of potassium iodide, in dimethyl formamide , heat at 85-90 ℃, Risperidone is generated, 46% yield.;

• Effective dose of Risperidone maintenance therapy reduces relapse rate of schizophrenia

  For treatment of newly diagnosed or recurrent acute schizophrenia, new antipsychotic efficacy are good, but the current maintenance therapy for acute treatment duration and dose has not yet been unified global consensus. This study is designed to investigate, ,the effects that the use of an effective dose of Risperidone maintenance treatment for different time have on disease recurrence after the acute phase treatment of schizophrenia patients is completed , and  verify the safety and tolerability long-term treatment with  Risperidone.
  The multicenter open randomized controlled study is participated by the National 19 psychiatric hospitals or psychiatric general hospitals,  Objects of study are  patients in line with the American Diagnostic and Statistical Manual Mental Disorders 4th edition (DSM-Ⅳ) schizophrenia diagnostic criteria , with previous episodes at least once,the total treatment time from this episode to join to the group, is ≤5 months,and they have been completed acute treatment and the symptoms are under control, they have been using fixed-dose Risperidone monotherapy for at least 4 weeks.Exclude patients use Risperidone in combination with  other antipsychotic drugs 30 days prior to enrollment .
  Patients are randomly divided into three groups, four weeks reduction groups: the group continue  to receive the effective dose of the acute phase for 4 weeks, followed by 8 weeks when the dose is gradually reduced to 1/2 of the original amount of treatment, followed by four weeks when doctors are allowed according to the patient's condition, efficacy and tolerability to decide whetherthe dose is further reduced to 1/4 of the original amount of treatment and to maintain this dose until the end of the study. 26 weeks reduction group: the group continue  to receive an effective dose of the acute phase of treatment for 26 weeks, followed by the same manner as in group A the dose is reduced and maintained to the end of treatment research. Continuous dose group: Use the effective dose of acute phase of treatment ,there is no reduction throughout the study period.
  The results show that using time to recurrence or relapse rate as the evaluation index, continuing with an effective dose of the acute phase of treatment for 4 weeks and 26 weeks , then reducing the dose, can not effectively reduce the recurrence rate. A group has the highest risk of recurrence which is 31.5%, and the results are very similar to those in Cscernansky  reports(  risk of recurrence using Risperidone for 28 months is 34%).  A long time for maintenance treatment or when continuing without reduction can reduce the risk of recurrence . Kane, etc. Using different doses of haloperidol decanoate maintenance therapy for 1 year ,finds that as the dose increases, relapse rate tends to decrease. The use of long-acting drugs actually  ensures that the dose is sustained,which also shows a lower relapse rate which is consistent with the results of this study.
  Studies have shown that after acute schizophrenia treatment, continue use of Risperidone in the acute phase of an effective dose without reduction maintenance therapy, which has the lowest risk of relapse and improves the symptoms  further, and does not increase  relatively common weight gain, extrapyramidal symptoms and menstrual disorders and so on significantly. These results indicate that, in order to reduce the relapse rate in patients with acute schizophrenia, the use of an effective dose of Risperidone maintenance treatment ≥6 months is necessary.;

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