Напроксен
- английское имяNaproxen
- CAS №22204-53-1
- CBNumberCB8274937
- ФормулаC14H14O3
- мольный вес230.26
- EINECS244-838-7
- номер MDLMFCD00010500
- файл Mol22204-53-1.mol
химическое свойство
| Температура плавления | 152-154 °C (lit.) |
| альфа | D +66° (in chloroform) |
| Температура кипения | 332.25°C (rough estimate) |
| плотность | 1.1450 (rough estimate) |
| показатель преломления | 67.5 ° (C=1, CHCl3) |
| Fp | 9℃ |
| температура хранения | 2-8°C |
| растворимость | Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol. |
| форма | powder |
| пка | pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain) |
| цвет | White to Almost white |
| оптическая активность | [α]25/D +66°, c = 1 in chloroform |
| Растворимость в воде | Insoluble in water. |
| Мерк | 14,6417 |
| БРН | 3591067 |
| BCS Class | 2 |
| LogP | 3.18 |
| Справочник по базе данных CAS | 22204-53-1(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| Словарь онкологических терминов NCI | Naprosyn; naproxen |
| FDA UNII | 57Y76R9ATQ |
| Словарь наркотиков NCI | Naprosyn |
| Код УВД | G02CC02,M01AE02,M02AA12 |
| Справочник по химии NIST | Naproxen(22204-53-1) |
| Система регистрации веществ EPA | 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)- (22204-53-1) |
больше
| Коды опасности | Xn,T,F | |||||||||
| Заявления о рисках | 22-39/23/24/25-23/24/25-11-36/37/38 | |||||||||
| Заявления о безопасности | 36/37-45-16-7-26 | |||||||||
| РИДАДР | UN 2811 6.1/PG 3 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | UF5275000 | |||||||||
| Класс опасности | 6.1(b) | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29189900 | |||||||||
| Банк данных об опасных веществах | 22204-53-1(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H335：Может вызывать раздражение верхних дыхательных путей.
H302：Вредно при проглатывании.
H411：Токсично для водных организмов с долгосрочными последствиями.
H361fd：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению. Предполагается, что данное вещество может отрицательно повлиять на неродившегося ребенка.
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оператор предупредительных мер
P202：Перед использованием ознакомиться с инструкциями по технике безопасности.
P273：Избегать попадания в окружающую среду.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Напроксен химические свойства, назначение, производство
Описание
Naproxen is synthesized from 2-methoxynaphthalene and the (+)-isomer obtained by resolution with cinchonidine (61). It was introduced in the United States in 1976 and, as a generic drug, has consistently been among the more popular NSAIDs. It is marketed as the S-(+)-enantiomer, but interestingly, the sodium salt of the (–)-isomer also is on the market as Anaprox. As an inhibitor of prostaglandin biosynthesis, it is 12 times more potent than aspirin, 10 times more potent than phenylbutazone, three to four times more potent than ibuprofen, and four times times more potent than fenoprofen, but it is approximately 300 times less potent than indomethacin.Химические свойства
white to light yellow crystal powdeИспользование
Being analogous to other drugs of this series, naproxene exhibits analgesic, fever-reducing, and long-lasting anti-inflammatory action. It causes reduction and removal of painful symptoms including joint pain, stiffness, and swelling in the joints. It is used in the same indications as ibuprofen.Показания
Naproxen (Naprosyn) also has pharmacological properties and clinical uses similar to those of ibuprofen. It exhibits approximately equal selectivity for COX-1 and COX-2 and is better tolerated than certain NSAIDs, such as indomethacin. Adverse reactions related to the GI tract occur in about 14% of all patients, and severe GI bleeding has been reported. CNS complaints (headache, dizziness, drowsiness), dermatological effects (pruritus, skin eruptions, echinoses), tinnitus, edema, and dyspnea also occur.Определение
ChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.Общее описание
Naproxen (Naprosyn, Anaprox), marketed as the (S)-enantiomer,is well absorbed after oral administration, givingpeak plasma levels in 2 to 4 hours and a half-life of 13 hours.Naproxen is highly protein bound and displaces most protein-bound drugs. It is recommended for use in RA, OA, acute gouty inflammation, and in primary dysmenorrhea. Itshows good analgesic activity (i.e., 400 mg is comparable to75–150 mg of oral meperidine and superior to 65 mg ofpropoxyphene and 325 mg of aspirin plus 30 mg of codeine).It is also available OTC as 200-mg tablets (Aleve).Фармакокине?тика
Naproxen is almost completely absorbed following oral administration. Peak plasma levels are achieved within 2 to 4 hours following administration. Like most of the acidic NSAIDs (pKa = 4.2), it is highly bound (99.6%) to plasma proteins. Approximately 70% of an administered dose is eliminated as either unchanged drug (60%) or as conjugates of unchanged drug (10%). The remainder is converted to the 6-O-desmethyl metabolite by both CYP3A4 and CYP1A2 and, further, to the glucuronide conjugate of the demethylated metabolite. The 6-O-desmethyl metabolite lacks anti-inflammatory activity. Like most of the arylalkanoic acids, the most common side effect associated with the use of naproxen is irritation to the GI tract. The most common other adverse reactions are associated with CNS disturbances (e.g., nausea and dizziness).Клиническое использование
Naproxen is indicated for the treatment of rheumatoid arthritis, osteoarthritis, juvenile arthritis, ankylosing spondylitis, tendinitis, bursitis, acute gout, and primary dysmenorrhea and for the relief of mild to moderate pain.Побочные эффекты
Common side effects of Naproxen may include indigestion, heartburn, stomach pain, nausea, headache, dizziness, drowsiness, bruising, itching, rash, swelling, or ringing in the ears. Seek immediate medical attention if you have any of the following serious drug reactions. For example: shortness of breath, swelling or rapid weight gain, rash, signs of stomach bleeding (bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds), liver problems (nausea, upper stomach pain, itching, feeling tired, flu-like symptoms, loss of appetite, dark urine, clay-coloured stools, jaundice), kidney problems (little or no urination, pain or difficulty in urinating, swelling of the feet or ankles, feeling tired or shortness of breath), low red blood cells (anaemia), etc. In addition, in rare cases, a severe allergic reaction to naproxen may occur. You may also suffer from stomach ulcers and other adverse reactions when taking it for a long time.Напроксен запасные части и сырье
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