Phorate

Описание

Phorate is a colorless oil. The water solubility is 50 mg/L (25 ?C). It is miscible with common organic solvents. Log Kow = 3.92. Phorate is relatively unstable to hydrolysis in aqueous media; DT₅₀ values at pH 7 and 9 are 3.2 and 3.9 d, respectively. Phorate is effective against sucking plant pests as a systemic insecticide-acaricide and also has good contact and vapor actions. It is usually formulated as granules. The acute oral LD₅₀ for rats is 1.6–3.7 mg/kg. Inhalation LC50 (1 h) for rats is 0.06–0.011 mg/L air. ADI is 0.5 μg/kg b.w.

Химические свойства

Phorate is a clear mobile liquid with a skunk-like odor

Использование

Phorate is a non-biocumulative organophosphate used as an insecticide and acaricide. Phorate is an inhibitor of acetylcholinesterase and pseudocholinesterase.

Общее описание

Clear liquid with an objectionable odor. Used as an insecticide and acaricide; Phorate is applied to plants and soil.

Реакции воздуха и воды

Phorate is incompatible with the following: Water, alkalis [Note: Hydrolyzed in the presence of moisture and by alkalis.] .

Профиль реактивности

Organothiophosphates, such as Phorate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Угроза здоровью

Phorate is one of the more toxic organophosphorus insecticides. It is a cholinesterase inhibitor that acts on the nervous system, and produces toxicity similar to Parathion. The probable oral lethal dose for humans is less than 5 mg/kg, i.e. a taste (less than 7 drops) for a 70 kg (150 lb.) person.

Пожароопасность

Shock can shatter containers, releasing the contents. When heated to decomposition, toxic fumes of sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted. Hydrolyzed in water and alkalies.

Сельскохозяйственное использование

Insecticide, Acaricide, Nematicide: Phorate is an organophosphorus insecticide and acaricide used to control a wide variety of sucking and chewing insects, leafhoppers, leafminers, mites, somenematodes, and rootworms. It is used on many crops, including root and field crops such as corn, cotton, coffee, potatoes, sugar beets, beans, peanuts, wheat, some ornamental and herbaceous plants, and bulb. In the U.S., 80% of the annual use of phorate is applied to corn, potatoes and cotton. It is available in granular and emulsifiable concentrate formulations. Phorate has been shown to be responsible for a large number of bird kills and it is extremely toxic to mammals. Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP). U.S. Maximum Allowable Residue Levels for Phorate (40 CFR 180.206): bean 0.1 ppm; beet, sugar, roots 0.3 ppm; beet, sugar, tops 3 ppm; coffee, bean 0.02 ppm; corn, forage 0.5 ppm; corn, grain 0.1 ppm; corn, sweet, kernel plus 0.1 ppm; cob with husks removed ppm; cotton, undelinted seed 0.05 ppm; hop 0.5 ppm; peanut 0.1 ppm; potato 0.5 ppm; sorghum, grain, grain 0.1 ppm; sorghum, grain, stover 0.1 ppm; soybean 0.1 ppm; sugarcane, cane 0.1 ppm; wheat, grain 0.05 ppm; wheat, hay 1.5 ppm; wheat, straw 0.05 ppm.

Торговое название

AASTAR®[C]; AC 3911®; AGRIMET®; AMERICAN CYANAMID 3,911®; EL 3911®; EXPERIMENTAL INSECTICIDE 3911®; GEOMET®; GRAMTOX®; GRANUTOX®; L 11/6®; METAPHOR®; PHORATE-10G®; PHORIL®; RAMPART®; TERRACLOR®; TERRATHION GRANULES®; THIMENOX®; THIMET®; THEMET®; UMET®; VEGFRU®; VERGFRU FORATOX®

Профиль безопасности

Poison by ingestion and sh contact routes. Experimental reproductive effects. Mutation data reported. A cholinesterase irhbitor. When heated to decomposition it emits toxic fumes of POx and SOx. See also PARATHION

Возможный контакт

Those engaged in the manufacture, formulation and application of this systemic and contact insecticide and acaricide. It is also used as a soil insecticide.

Канцерогенность

When dogs were given phorate via capsules at doses of 0.005, 0.01, 0.05, or 0.25 mg/kg/day for 1 year, slight body tremors, marginal inhibition of body weight gain, and RBC and brain cholinesterase inhibition occurred in males given 0.25 mg/kg/day .
No evidence of carcinogenicity occurred in rats given diets that contained 0, 1, 3, or 6 ppm phorate (equal to about 0, 0.05, 0.15, or 0.3 mg/kg/day) for 2 years . Erythrocyte and brain cholinesterase inhibition occurred at exposures of 3 and 6 ppm. No evidence of carcinogenicity or other adverse effects occurred in mice given diets that contained 0, 1, 3, or 6 ppm phorate (equal to about 0, 0.15, 0.45, and 0.9 mg/kg/day) for 78 weeks, other than a slight decrease in body weight gain in females that were fed 6 ppm .

Метаболический путь

Phorate is metabolised by an analogous route to that of disulfoton. The principal route of phorate metabolism in all media is activation via oxidation of the thioether group to the sulfoxide (rapid) and sulfone (slower). Thioether oxidation occurs preferentially to oxidative desulfuration of the P=S group to the oxon, which is usually only present in trace amounts, and there is good evidence that the sulfoxide and sulfone oxons arise via phorate sulfoxide and sulfone rather than phorate oxon. The more polar thiooxidised metabolites are translocated in plants and are responsible for the compound’s systemic action. Of all phorate’s metabolites, phorate oxon sulfone is the most active inhibitor of acetylcholinesterase (Bowman and Casida, 1957). Degradative metabolism occurs via oxidative dealkylation of the phosphorodithioate group or hydrolysis of the oxon.

Метаболизм

The metabolic routes of phorate are essentially the same in plants, animals, and soils, involving the oxidation of the sulfide group into the sulfoxide then sulfone, and oxidative desulfuration to the corresponding oxons, followed by hydrolysis to diethyl hydrogen phosphorodithioate, phosphorothioate, and phosphate. Phorate protects plants for a relatively long time because of the persistency of the sulfoxide metabolite in plants and in soils. DT₅₀ in soil is 2–14 d.

Перевозки

UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Несовместимости

Water, alkalis. Hydrolyzed in the presence of moisture and by alkalis; may produce toxic oxides of phosphorus and sulfur. Strong oxidizers may cause release of toxic phosphorus oxides. Organophosphates, in the presence of strong reducing agents such as hydrides, may form highly toxic and flammable phosphine gas. Keep away from alkaline materials.

Утилизация отходов

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.