298-02-2

Clear liquid with an objectionable odor. Used as an insecticide and acaricide; PHORATE(298-02-2) is applied to plants and soil.

Organothiophosphates, such as PHORATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

This compound is incompatible with the following: Water, alkalis [Note: Hydrolyzed in the presence of moisture and by alkalis.] .

This material is one of the more toxic organophosphorus insecticides. It is a cholinesterase inhibitor that acts on the nervous system, and produces toxicity similar to Parathion. The probable oral lethal dose for humans is less than 5 mg/kg, i.e. a taste (less than 7 drops) for a 70 kg (150 lb.) person.

Those engaged in the manufacture, formulation and application of this systemic and contact insecticide and acaricide. It is also used as a soil insecticide.

Shock can shatter containers, releasing the contents. When heated to decomposition, toxic fumes of sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted. Hydrolyzed in water and alkalies.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous material. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Water, alkalis. Hydrolyzed in the presence of moisture and by alkalis; may produce toxic oxides of phosphorus and sulfur. Strong oxidizers may cause release of toxic phosphorus oxides. Organophosphates, in the presence of strong reducing agents such as hydrides, may form highly toxic and flammable phosphine gas. Keep away from alkaline materials.

Phorate is a clear mobile liquid with a skunk-like odor

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Insecticide.

Phorate is a non-biocumulative organophosphate used as an insecticide and acaricide. Phorate is an inhibitor of acetylcholinesterase and pseudocholinesterase.

Phorate is a systemic insecticide used to control sucking and chewing pests in a very wide range of crops. It is also active as a nematicide and has some vapour phase activity.

Systemic insecticide for control of mites, chewing and sucking insects in fruits and vegetables, cotton and some ornamentals

ChEBI: Phorate is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to an (ethylsulfanyl)methanethiol.

Insecticide, Acaricide, Nematicide: Phorate is an organophosphorus insecticide and acaricide used to control a wide variety of sucking and chewing insects, leafhoppers, leafminers, mites, somenematodes, and rootworms. It is used on many crops, including root and field crops such as corn, cotton, coffee, potatoes, sugar beets, beans, peanuts, wheat, some ornamental and herbaceous plants, and bulb. In the U.S., 80% of the annual use of phorate is applied to corn, potatoes and cotton. It is available in granular and emulsifiable concentrate formulations. Phorate has been shown to be responsible for a large number of bird kills and it is extremely toxic to mammals. Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP). U.S. Maximum Allowable Residue Levels for Phorate (40 CFR 180.206): bean 0.1 ppm; beet, sugar, roots 0.3 ppm; beet, sugar, tops 3 ppm; coffee, bean 0.02 ppm; corn, forage 0.5 ppm; corn, grain 0.1 ppm; corn, sweet, kernel plus 0.1 ppm; cob with husks removed ppm; cotton, undelinted seed 0.05 ppm; hop 0.5 ppm; peanut 0.1 ppm; potato 0.5 ppm; sorghum, grain, grain 0.1 ppm; sorghum, grain, stover 0.1 ppm; soybean 0.1 ppm; sugarcane, cane 0.1 ppm; wheat, grain 0.05 ppm; wheat, hay 1.5 ppm; wheat, straw 0.05 ppm.

AASTAR®[C]; AC 3911®; AGRIMET®; AMERICAN CYANAMID 3,911®; EL 3911®; EXPERIMENTAL INSECTICIDE 3911®; GEOMET®; GRAMTOX®; GRANUTOX®; L 11/6®; METAPHOR®; PHORATE-10G®; PHORIL®; RAMPART®; TERRACLOR®; TERRATHION GRANULES®; THIMENOX®; THIMET®; THEMET®; UMET®; VEGFRU®; VERGFRU FORATOX®

When dogs were given phorate via capsules at doses of 0.005, 0.01, 0.05, or 0.25 mg/kg/day for 1 year, slight body tremors, marginal inhibition of body weight gain, and RBC and brain cholinesterase inhibition occurred in males given 0.25 mg/kg/day .
No evidence of carcinogenicity occurred in rats given diets that contained 0, 1, 3, or 6 ppm phorate (equal to about 0, 0.05, 0.15, or 0.3 mg/kg/day) for 2 years . Erythrocyte and brain cholinesterase inhibition occurred at exposures of 3 and 6 ppm. No evidence of carcinogenicity or other adverse effects occurred in mice given diets that contained 0, 1, 3, or 6 ppm phorate (equal to about 0, 0.15, 0.45, and 0.9 mg/kg/day) for 78 weeks, other than a slight decrease in body weight gain in females that were fed 6 ppm .

Biological. [14C]Phorate degraded in a model ecosystem consisting of soil, plants and water (Lichtenstein et al., 1974). Under both non-percolating and percolating water conditions, 12% of the applied amount migrated downward as the corresponding sulfone and sulfoxide. Phorate was absorbed in the roots of corn and was transformed primarily to the sulfone with trace amounts of the sulfoxide. Translocation of radioactive insecticide to the leaves was also observed but the major products were identified as phoratoxon sulfone and phoratoxon sulfoxide (Lichtenstein et al., 1974)
From the first-order biotic and abiotic rate constants of phorate in estuarine water and sediment/water systems, the estimated biodegradation half-lives were 1.1–1.6 and 0.7–1.6 days, respectively (Walker et al., 1988)
Soil. The corresponding sulfoxide and sulfone and their phosphorothioate analogs are major soil metabolites (Lichtenstein et al., 1974). The phosphorothioate analogs may hydrolyze forming dithio-, thio- and orthophosphoric acids (Hartley and Kidd
Phorate was moderately persistent in soil. Way and Scopes (1968) reported residues comprised 10% of applied dosage 540 days after application. The reported half-life in soil is 82 days (Jury et al., 1987) and 68 days in a sandy soil (Way and Scopes, 1968). The half-lives for phorate in soil incubated in the laboratory under aerobic conditions ranged from 7 to 82.5 days with an average half-life of 75 days (Getzin and Chapman, 1960; Getzin and Shark, 1970). Approximately three days after applying phorate to a sandy soil, 41% was lost to volatilization (Burns, 1971)
Plant. Oat plants were grown in two soils treated with [14C]phorate. Most of the residues remained bound to the soil. Less than 2% of the applied [14C]phorate was recovered from the oat leaves. The major residues in soil were phorate and the corr

Phorate is metabolised by an analogous route to that of disulfoton. The principal route of phorate metabolism in all media is activation via oxidation of the thioether group to the sulfoxide (rapid) and sulfone (slower). Thioether oxidation occurs preferentially to oxidative desulfuration of the P=S group to the oxon, which is usually only present in trace amounts, and there is good evidence that the sulfoxide and sulfone oxons arise via phorate sulfoxide and sulfone rather than phorate oxon. The more polar thiooxidised metabolites are translocated in plants and are responsible for the compound’s systemic action. Of all phorate’s metabolites, phorate oxon sulfone is the most active inhibitor of acetylcholinesterase (Bowman and Casida, 1957). Degradative metabolism occurs via oxidative dealkylation of the phosphorodithioate group or hydrolysis of the oxon.

The metabolic routes of phorate are essentially the same in plants, animals, and soils, involving the oxidation of the sulfide group into the sulfoxide then sulfone, and oxidative desulfuration to the corresponding oxons, followed by hydrolysis to diethyl hydrogen phosphorodithioate, phosphorothioate, and phosphate. Phorate protects plants for a relatively long time because of the persistency of the sulfoxide metabolite in plants and in soils. DT₅₀ in soil is 2–14 d.

Phorate in aqueous solution is hydrolysed and degraded by light. The half-lives at pH 7 and 9 were 3.2 and 3.9 days, respectively (PM). When exposed to sunlight or UV light phorate was apparently oxidised to products which were more active inhibitors of acetylcholinesterase than phorate or its sulfoxide (Bowman and Casida, 1957). Although not specifically identified these photolysis products were likely to be the thiooxidised phorate oxon.