1,3-ДИМЕТИЛМОЧЕВИНА

Химические свойства

white crystals

Использование

N,N′-Dimethylurea can be used:

• As a starting material to synthesize N,N′-dimethyl-6-amino uracil.
• In combination with β-cyclodextrin derivatives, to form low melting mixtures (LMMs), which can be used as solvents for hydroformylation and Tsuji-Trost reactions.
• To synthesize N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones via Biginelli condensation under solvent-free conditions.

Определение

ChEBI: A member of the class of ureas that is urea substituted by methyl groups at positions 1 and 3.

Общее описание

Colorless crystals.

Реакции воздуха и воды

Water soluble.

Профиль реактивности

1,3-Dimethylurea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Угроза здоровью

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-Dimethylurea emits toxic fumes.

Пожароопасность

Flash point data for 1,3-Dimethylurea are not available; 1,3-Dimethylurea is probably combustible.

Профиль безопасности

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Методы очистки

Crystallise the urea from acetone/diethyl ether by cooling in an ice bath. Also crystallise it from EtOH and dry it at 50o/5mm for 24hours [Bloemendahl & Somsen J Am Chem Soc 107 3426 1985]. [Beilstein 4 IV 207.]