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Метиламин
- английское имяMethylamine
- CAS №74-89-5
- CBNumberCB4387750
- ФормулаCH5N
- мольный вес31.06
- EINECS200-820-0
- номер MDLMFCD00008104
- файл Mol74-89-5.mol
Температура плавления | -93 °C(lit.) |
Температура кипения | -6.3 °C(lit.) |
плотность | 0.785 g/mL at 25 °C |
плотность пара | 1.08 (20 °C, vs air) |
давление пара | 27 psi ( 20 °C) |
показатель преломления | n |
Fp | 61 °F |
температура хранения | Store below +30°C. |
растворимость | highly soluble in water (108g/100g) at 25°C; soluble in alcohol and miscible with ether; HCl salt is soluble in water and absolute alcohol; compound is insoluble in chloroform, acetone, ether, and ethyl acetate |
пка | 10.63(at 25℃) |
форма | Gas |
Удельный вес | 0.901 (20℃/4℃) (40% Soln.) |
РН | 14 (H2O, 20°C) |
Порог?обнаружения?запаха? | 0.035ppm |
Пределы взрываемости | 4.9-20.8% |
Растворимость в воде | Miscible with water, ethanol, benzene, acetone and ether. |
Мерк | 14,6014 |
БРН | 741851 |
констант закона Генри | (x 10-5 atm?m3/mol): 1.11 at 25 °C (Christie and Crisp, 1967) |
Пределы воздействия | TLV-TWA 10 ppm (~12.3 mg/m3)(ACGIH, MSHA, and OSHA); IDLH 100 ppm (NIOSH). |
Диэлектрическая постоянная | 10.0(18℃) |
Стабильность | Stable. Highly flammable. Note wide explosion limits. Incompatible with oxidizing agents, acids, alkalies, alkaline earth metals, copper and its alloys, zinc and its alloys. |
LogP | -0.570 |
Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | METHYLAMINE |
Справочник по базе данных CAS | 74-89-5(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 2-4 |
FDA UNII | BSF23SJ79E |
Система регистрации веществ EPA | Methylamine (74-89-5) |
Коды опасности | F+,Xn,C,F,T | |||||||||
Заявления о рисках | 12-20-37/38-41-34-20/22-11-39/23/24/25-36/37/38-23/24/25-40-19 | |||||||||
Заявления о безопасности | 7-16-26-36/37-45-29-36/37/39-3/7-3-39-33 | |||||||||
РИДАДР | UN 3286 3/PG 2 | |||||||||
OEB | A | |||||||||
OEL | TWA: 10 ppm (12 mg/m3) | |||||||||
WGK Германия | 2 | |||||||||
RTECS | PF6300000 | |||||||||
F | 4.5-31 | |||||||||
Температура самовоспламенения | 806 °F | |||||||||
TSCA | Yes | |||||||||
Классификация DOT | 2.1 (Flammable gas) | |||||||||
Класс опасности | 3 | |||||||||
Группа упаковки | II | |||||||||
кода HS | 29211100 | |||||||||
Банк данных об опасных веществах | 74-89-5(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orally in rats: 100-200 mg/kg (Kinney); LC50 in rats: 0.448 ml/l (Sarkar, Sastry) | |||||||||
ИДЛА | 100 ppm | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H335:Может вызывать раздражение верхних дыхательных путей.
H314:При попадании на кожу и в глаза вызывает химические ожоги.
H225:Легковоспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
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оператор предупредительных мер
P210:Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P233:Держать в плотно закрытой/герметичной таре.
P240:Заземлить и электрически соединить контейнер и приемное оборудование.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P303+P361+P353:ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Метиламин химические свойства, назначение, производство
Химические свойства
Methylamine is a colorless, fi sh-like smelling gas at room temperature. It is used in a variety of industries, such as the manufacture of dyestuffs, treatment of cellulose, acetate rayon, as a fuel additive, rocket propellant, and in leather tanning processes.Физические свойства
Colorless, flammable gas with a strong ammonia-like odor. An experimentally determined recognition odor threshold concentration of 21 ppbv was reported by Leonardos et al. (1969). Odor threshold concentrations of 4.7 ppmv and 35 ppbv were experimentally determined by Nishida et al. (1979) and Nagata and Takeuchi (1990), respectively.Использование
Methylamine is used in dyeing and tanning;in photographic developer, as a fuel additive,and as a rocket propellant. It is also usedin organic synthesis and as a polymerizationinhibitor. It occurs in certain plants, such asMentha aquatica.Методы производства
Several methods are currently used for synthesis of methylamine. Virtually all produce a mixture of primary, secondary, and tertiary amines which can be continuously separated by distillation and extraction. The most commonly used synthesis involves heating ammonium chloride and methyl alcohol (ratio varies from 2:1 to 6:1, depending on desired ratio of amines) to about 300°C in the presence of a catalyst such as zinc chloride. Alternatively, methylamine can be synthesized by heating ammonium chloride and formaldehyde in the presence of H2 and a hydrogenation catalyst such as nickel or platinum. Methylamine is generally marketed as a liquid or a 33% aqueous solution (HSDB 1988).Определение
ChEBI: The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.Общее описание
A colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at 20.3°F hence vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.Реакции воздуха и воды
Highly flammable. Very soluble in water; the solutions are strongly basic and therefore corrosive. Liquid fumes in air.Профиль реактивности
METHYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.Опасность
(Gas and liquid) Dangerous fire risk. Explosive limits in air 5–21%. Strong irritant to tissue. Eye, skin and upper respiratory tract irritant.Угроза здоровью
Exposures to methylamine are known to cause adverse health effects among occupational workers. The workers demonstrate symptoms of toxicity that include, but are not limited to, irritation to the eyes, nose, and throat. Studies have indicated that the compound causes injury to the eyes through corneal opacities and edema hemorrhages in the conjunctiva, and injury to the liver. Studies of Guest and Varma indicated no signifi cant deleterious effects on the internal organs or skeletal deformities in experimental miceПожароопасность
FLAMMABLE. POISONOUS GASES MAY BE PRODUCED IN FIRE. Containers may explode in fire. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic nitrogen oxides may be formed. Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back.Промышленное использование
Methylamine and its hydrochloride salt are widely used in organic synthesis for introducing the methylamino group. In 1976, industrial consumption was 32,000 tons/year. One of its most important uses is in the preparation of amide-type surfactants. It is also used in the preparation of drugs such as adrenaline and synthetic caffeine. It serves as the base for more than twenty commercial products, among those included are photographic developers, insecticides, and antihistamine drugs (Beard and Noe 1981). It is also widely used in tanning and has been used in the separation of aromatics from aliphatic hydrocarbons (Sittig 1981).Профиль безопасности
Poison by subcutaneous route. Moderately toxic by inhalation. A severe skin irritant. Mutation data reported. A strong base. Flammable gas at ordinary temperature and pressure. Very dangerous fire hazard when exposed to heat, flame, or sparks. Explosive when exposed to heat or flame. To fight fire, stop flow of gas. Forms an explosive mixture with nitromethane. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.Возможный контакт
Methylamine is used in organic synthesis; a starting material for N-oleyltaurine, a surfactant; and p-N-methylaminophenol sulfate, a photographic developer. It has possible uses in solvent extraction systems in separation of aromatics from aliphatic hydrocarbons. It is also used in the synthesis of many different pharmaceuticals; pesticides and rubber chemicals.Канцерогенность
Methylamine was positive in the mouse lymphoma assay and negative in the Ames assay.Экологическая судьба
Photolytic. The rate constant for the reaction of methylamine and OH radicals in the atmosphere at 300 K is 1.3 x 10-13 cm3/molecule?sec (Hendry and Kenley, 1979).Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. In an aqueous solution, chloramine reacted with methylamine to form Nchloromethylamine (Isaac and Morris, 1983).
Reacts with acids forming water-soluble salts.
хранилище
Methylamine is stored in a cool, well-ventilated noncombustible area separatedfrom possible sources of ignition andoxidizing substances and mercury. Itssolutions are stored in a flammable liquidstorage room or cabinet. The gas is shippedin steel cylinders or tank cars; the liquid isshipped in steel drums or tank cars.Перевозки
UN1061 Methylamine, anhydrous, Hazard Class: 2.1; Labels: 2.1-Flammable gas. UN1235 Methylamine, aqueous solution, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.Методы очистки
Dry the amine with sodium or BaO. It is commercially available in metal cylinders. [Beilstein 4 IV 118.]Несовместимости
A medium-strong base. Reacts violently with strong acids; mercury, strong oxidizers; nitromethane. Corrosive to copper, zinc alloys; aluminum, and galvanized surfaces.Утилизация отходов
Return refillable compressed gas cylinders to supplier. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).Метиламин запасные части и сырье
сырьё
запасной предмет
- N-Methyl-4-pyridinamine
- 3-Hydrazinyl-N-methylpropanamide
- N-Cyano-N'-methyl-ethanimidamide
- sodium oleyl sarcosinate
- additive AC1210
- fluorescent whitening agent AT
- didodecyl dimethyl ammoniumm
- 2-МЕТОКСИФЕНАМИН HCL
- 1-Methyl-3-phenyl-2-thiourea
- BIFEMELANE
- N,N-DIMETHYL-4-[(METHYLAMINO)METHYL]ANILINE
- Noncyanide zinc plating additive DE
- 3,4,5-TRIMETHACARB
- METHYL-(2-TRIFLUOROMETHYL-BENZYL)-AMINE
- CHLOROMETHYLACETAMIDE
- 4-Хлор-N-метиланилина
- 4-фтор-N-метилбензиламин
- N-Methylpentylamine
- 3-фтор-N-метилбензиламин
- Disperse Red 9
- 2-CHLORO-N-METHYLACETOACETAMIDE
- Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
- 1,3-ДИМЕТИЛМОЧЕВИНА
- Золпидем
- РОТЕНОН
- N-(4-амино-6-этокси-1,3,5-триазин-2-ил)-N-метиламин
- (1H-IMIDAZOL-2-YLMETHYL)-METHYL-AMINE
- 3-Метокси-N-метилбензиламин
- Боннекор
- 2-Hydrazinyl-N-methylacetamide
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Метиламин Обзор)
- Диметиламин
- Триметиламин
- N-Phenylbis (трифторметансульфонимид)
- Тозилметил изоцианид
- 4-бром-N,N-диметиланилин
- N-Метил-N-(триметилсилил)трифторацетамид
- Диэтиламиносера трифторид
- 4'-бромацетанилид
- трет-Бутилизоцианид
- 3-метокси-5-(трифторметил) анилина
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