ДИБУТИЛФТАЛАТ
- английское имяDibutyl phthalate
- CAS №84-74-2
- CBNumberCB7161937
- ФормулаC16H22O4
- мольный вес278.34
- EINECS201-557-4
- номер MDLMFCD00009441
- файл Mol84-74-2.mol
химическое свойство
| Температура плавления | -35 °C (lit.) |
| Температура кипения | 340 °C (lit.) |
| плотность | 1.043 g/mL at 25 °C (lit.) |
| плотность пара | 9.6 (vs air) |
| давление пара | 1 mm Hg ( 147 °C) |
| показатель преломления | n |
| Fp | 340 °F |
| температура хранения | 2-8°C |
| растворимость | Very soluble in alcohol, ether, acetone, benzene |
| форма | Liquid |
| Удельный вес | 1.049 (20/20℃) |
| цвет | APHA: ≤10 |
| Относительная полярность | 0.272 |
| Запах | odorless |
| Вязкость | 18.8mm2/s |
| Пределы взрываемости | 0.47%, 236°F |
| Растворимость в воде | Slightly soluble. 0.0013 g/100 mL |
| Точка замерзания | -35℃ |
| Мерк | 14,3035 |
| БРН | 1914064 |
| констант закона Генри | 6.3 x 10-5 atm?m3/mol (quoted, Petrasek et al., 1983) |
| Пределы воздействия | NIOSH REL: TWA 5 mg/m3, IDLH 4,000 mg/m3; OSHA PEL: TWA 5 mg/m3; ACGIH TLV: TWA 5 mg/m3. |
| Диэлектрическая постоянная | 6.0（45℃） |
| ИнЧИКей | DOIRQSBPFJWKBE-UHFFFAOYSA-N |
| LogP | 4.46-4.57 at 20-30℃ |
| Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | DIBUTYL PHTHALATE |
| FDA 21 CFR | 175.105; 176.170; 176.300; 177.1200; 177.2600 |
| Справочник по базе данных CAS | 84-74-2(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 7-10 |
| FDA UNII | 2286E5R2KE |
| Предложение 65 Список | Di-n-butyl Phthalate (DBP) |
| Код УВД | P03BX03 |
| Справочник по химии NIST | Dibutyl phthalate(84-74-2) |
| Система регистрации веществ EPA | Dibutyl phthalate (84-74-2) |
больше
| Коды опасности | T,N,F | |||||||||
| Заявления о рисках | 61-50-62-39/23/24/25-23/24/25-11 | |||||||||
| Заявления о безопасности | 53-45-61-36/37-16 | |||||||||
| РИДАДР | UN 3082 9/PG 3 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 5 mg/m3 | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | TI0875000 | |||||||||
| Температура самовоспламенения | 756 °F | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 9 | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29173100 | |||||||||
| Банк данных об опасных веществах | 84-74-2(Hazardous Substances Data) | |||||||||
| Токсичность | Acute oral LD50 for rats 8,000 mg/kg (RTECS, 1985). | |||||||||
| ИДЛА | 4,000 mg/m3 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
H360FD：Может отрицательно повлиять на способность к деторождению. Может отрицательно повлиять на неродившегося ребенка.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P273：Избегать попадания в окружающую среду.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
ДИБУТИЛФТАЛАТ химические свойства, назначение, производство
Описание
Dibutyl phthalate is included as an insect repellent in some aerosol sprays used to treat flystrike in sheep. It is colorless oily liquid with a very weak aromatic odor.Химические свойства
Dibutyl phthalate occurs as an odorless, oily, colorless, or very slightly yellow-colored, viscous liquid.Физические свойства
Colorless to pale yellow, oily, viscous liquid with a mild, aromatic odorИспользование
Dibutyl phthalate is used in plasticizers, cosmetics, safety glass, insecticides, printing inks, paper coatings, adhesives, elastomers and explosives; solvent in polysulfide dental impression materials; solvent for perfume oils; perfume fixative; textile lubricating agent; solid rocket propellent; emollient in aerosol antiperspirants; insect repeller; plasticizer in various plastic materials.Методы производства
Dibutyl phthalate is produced from n-butanol and phthalic anhydride in an ester formation reaction.Определение
ChEBI: Dibutyl phthalate is a phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans. It has a role as an environmental contaminant, a teratogenic agent, a plasticiser, a metabolite and an EC 3.2.1.20 (alpha-glucosidase) inhibitor. It is a phthalate ester and a diester. It is functionally related to a butan-1-ol.Общее описание
Dibutyl phthalate is a colorless oily liquid. Dibutyl phthalate is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since Dibutyl phthalate is a liquid Dibutyl phthalate can easily penetrate the soil and contaminate groundwater and nearby streams. Dibutyl phthalate is combustible though Dibutyl phthalate may take some effort to ignite. Dibutyl phthalate is used in paints and plastics and as a reaction media for chemical reactions.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Dibutyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Avoid contact with strong oxidizing agents and strong bases. Will not polymerize. [USCG, 1999]. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].Угроза здоровью
The toxicity of this compound is very low. Inhumans, oral intake of dibutyl phthalate at adose level of 150 mg/kg may cause nausea,vomiting, dizziness, hallucination, distortedvision, lacrimation, and conjunctivitis withprompt recovery. It metabolizes to monobutylester and phthalic acid and is excreted in urine.The inhalation toxicity should be insignificantbecause of its negligible low vapor pressure[<0.1 torr at 20°C (68°F)]. However, expo sure to its mist or aerosol can cause irritationof eyes and mucous membranesLD50 value, oral (mice): 5300 mg/kg.
Пожароопасность
Combustible.Фармацевтические приложения
Dibutyl phthalate is used in pharmaceutical formulations as a plasticizer in film-coatings. It has been evaluated as a pore-forming agent in novel delivery systems.It is also used extensively as a solvent, particularly in cosmetic formulations such as antiperspirants, hair shampoos, and hair sprays. In addition to a number of industrial applications, dibutyl phthalate is used as an insect repellent, although it is not as effective as dimethyl phthalate.Контактные аллергены
It is mainly used as a nonreactive epoxy diluent.Профиль безопасности
Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by ingestion. Human systemic eye effects by ingestion, hallucinations, dstorted perceptions, nausea or vomiting, and kidney, ureter, or bladder changes. Experimental teratogenic and reproductive effects. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. Violent reaction with Cl2. Incompatible with chlorine. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS, PHTHALIC ACID, and n BUTYL ALCOHOL.Безопасность
Dibutyl phthalate is generally regarded as a relatively nontoxic material, although it has occasionally been reported to cause hypersensitivity reactions. It is widely used in topical cosmetic and some oral pharmaceutical formulations.LD50 (mouse, IV): 0.72g/kg
LD50 (mouse, oral): 5.3g/kg
LD50 (rat, oral): 8.0g/kg
LD50 (rat, IP): 3.05mL/kg
хранилище
Dibutyl phthalate should be stored in a well-closed container in a cool, dry, location. Containers may be hazardous when empty since they can contain product residues such as vapors and liquids.Методы очистки
Wash DBP with H2O (to free it from alcohol), then dilute NaOH (to remove any butyl hydrogen phthalate or acid), aqueous NaHCO3 (charcoal), then distilled water. Dry it (CaCl2), distil it at 10torr or less, and store it in a desiccator over P2O5. [Beilstein 9 II 586, 9 III 4102, 9 IV 3175.]Несовместимости
Dibutyl phthalate reacts violently with chlorine. It also reacts with oxidizing agents, acids, bases, and nitrates.Регуляторный статус
Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and controlled release tablets). Included in nonparenteral medicines licensed in the UK (oral capsules, tablets, granules; topical creams and solutions).ДИБУТИЛФТАЛАТ запасные части и сырье
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