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Бромбензол
- английское имяBromobenzene
- CAS №108-86-1
- CBNumberCB6235569
- ФормулаC6H5Br
- мольный вес157.01
- EINECS203-623-8
- номер MDLMFCD00000055
- файл Mol108-86-1.mol
Температура плавления | -31 °C |
Температура кипения | 156 °C(lit.) |
плотность | 1.491 g/mL at 25 °C(lit.) |
плотность пара | 5.41 (vs air) |
давление пара | 10 mm Hg ( 40 °C) |
показатель преломления | n |
Fp | 124 °F |
температура хранения | Store below +30°C. |
растворимость | Miscible with diethyl ether, alcohol, carbon tetrachloride, chloroform and benzene. |
форма | Liquid |
цвет | Clear colorless to faintly yellow |
Запах | pleasant smell |
Пределы взрываемости | 0.5-2.5%(V) |
Растворимость в воде | insoluble. <0.1 g/100 mL at 20.5 ºC |
Мерк | 14,1406 |
БРН | 1236661 |
констант закона Генри | 2.47 at 25 °C (gas stripping-GC, Shiu and Mackay, 1997) |
Диэлектрическая постоянная | 5.4(20℃) |
Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents. |
ИнЧИКей | QARVLSVVCXYDNA-UHFFFAOYSA-N |
LogP | 3.14 at 25℃ |
Справочник по базе данных CAS | 108-86-1(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 2 |
FDA UNII | CO4D5J547L |
Справочник по химии NIST | Benzene, bromo-(108-86-1) |
Система регистрации веществ EPA | Bromobenzene (108-86-1) |
Коды опасности | Xi,N,F,T | |||||||||
Заявления о рисках | 10-38-51/53-39/23/24/25-23/24/25 | |||||||||
Заявления о безопасности | 61-45-36/37 | |||||||||
РИДАДР | UN 2514 3/PG 3 | |||||||||
WGK Германия | 2 | |||||||||
RTECS | CY9000000 | |||||||||
Температура самовоспламенения | 565 °C | |||||||||
TSCA | Yes | |||||||||
кода HS | 2903 99 80 | |||||||||
Класс опасности | 3 | |||||||||
Группа упаковки | III | |||||||||
Банк данных об опасных веществах | 108-86-1(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orally in Rabbit: 2383 mg/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H411:Токсично для водных организмов с долгосрочными последствиями.
H226:Воспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
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оператор предупредительных мер
P210:Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P273:Избегать попадания в окружающую среду.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
Бромбензол химические свойства, назначение, производство
Химические свойства
Bromobenzene, also known as phenyl bromide and monobromobenzene, is a benzene halogen derivative generated by benzene being substituted by bromine in the presence of iron powder. The chemical reaction principle is the same as that of chlorination of benzene to produce chlorobenzene. The reaction between bromobenzene and metal magnesium can generate phenylmagnesium bromide, which is a Grignard reagent with important uses in organic synthesis.Физические свойства
Mobile, clear, colorless to pale yellow liquid with an aromatic odor. The reported odor threshold is 4.6 ppm (Mateson, 1955). Insoluble in water, soluble in benzene, alcohol, ether, chlorobenzene and other organic solvents. It is irritating to the skin and anesthetic to the nerves. Its toxicity is stronger than chlorobenzene. Inhalation of its vapors can cause anemia and damage the liver.Использование
Bromobenzene is a colorless, flammable liquid with a density greater than water and with an aromatic odor. It is synthesized by the reaction of bromide with benzene in the presence of iron powder. It is used for organic synthesis, particularly in the production of the intermediate phenylmagnesium bromide. Bromobenzene is an additive to motor oils and used as a crystallizing solvent. It is used as an ingredient in the manufacture of phencyclidine, a recreational drug.Подготовка
Bromobenzene is obtained by reacting benzene with bromine. First add iron powder and benzene into the reactor, slowly add bromine under stirring, keep the reaction at 70-80°C for 1 h after adding, the obtained crude product is washed with water and 5% sodium hydroxide solution, left to stand for stratification, distillation, Drying, filtering, and finally fractional distillation under constant pressure, taking the fraction at 155-157°C to obtain the finished product.прикладной
The compound is employed as a starting material in organic syntheses in which a Grignard intermediate (phenyl magnesium bromide) is used. The material is a chemical precursor for certain agricultural products and has been used as an additive to motor oils. Bromobenzene has also been used as a high-density solvent for chemical recrystallization processes. especially for crystallizations on a large scale and where a heavy liquid is desirable.Определение
ChEBI: Bromobenzene is the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30℃; b.p.760 156℃), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis. It has a role as a non-polar solvent, a hepatotoxic agent and a mouse metabolite. It is a member of bromobenzenes, a bromoarene and a volatile organic compound.Общее описание
Mobile clear colorless liquid with a pungent odor. Flash point 124°F. Denser than water and insoluble in water. Hence sinks in water. Vapors are heavier than air. A skin irritant.Реакции воздуха и воды
Flammable. Insoluble in water.Профиль реактивности
Bromobenzene may be sensitive to light. May react with oxidizing agents .Пожароопасность
Moderate fire risk. Special Hazards of Combustion Products: Irritating hydrogen bromide and other gases may be produced in fire.Профиль безопасности
Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. LWdly toxic by inhalation. An eye and mucous membrane irritant. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. Can react with oxidtzing materials. To fight fire, use water to blanket fire, foam, CO2, water spray or mist, dry chemical. Violent reaction with bromobutane + sodium when heated above 30℃. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.Экологическая судьба
Bromobenzene will volatilize from dry surfaces, due to its vapor pressure of 4.18mmHg at 25°C, and therefore will exist as a vapor in the environment. Bromobenzene will undergo little hydrolysis in water and little biodegradation by aquatic microorganisms. Bromobenzene is not expected to adsorb to sediment from water due to its soil sorption constant (Koc) of 150 and water solubility of 446 mg l-1. It is also expected to have a high mobility in soil and volatilize easily from moist surfaces due to its Henry’s law constant of 2.47×10-3 atmm3 mol-1 at 25°C. Bioconcentration factors range from low values of 8.8 in carp to moderately high values of 190 in algae.Метаболический путь
Bromobenzene and chlorobenzene are metabolized by human and mouse hepatic microsomes to two different epoxide intermediates, which rearrange to form either o- or p-bromo- and o- or p-chlorophenols, respectively. Humans preferentially metabolize halobenzenes through the hepatotoxic 3,4-epoxide pathway, suggesting that humans may be more susceptible than mice to halobenzene-induced hepatotoxicity.Методы очистки
Wash bromobenzene vigorously with conc H2SO4, then 10% NaOH or NaHCO3 solutions, and H2O. Dry it with CaCl2 or Na2SO4, or pass it through activated alumina, before refluxing with, and distilling from, CaH2, using a glass helix-packed column. [Beilstein 5 IV 670.]Токсикология
The acute toxicity of bromobenzene is lowin test animals. The toxic symptoms includesomnolence, respiratory stimulation, and muscle contraction. The oral LD50 value in rats is2700 mg/kg.Бромбензол запасные части и сырье
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