Доксепин

Использование

Used clinically to treat anxiety and depression. Antidepressant

Определение

ChEBI: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Всемирная организация здравоохранения(ВОЗ)

Doxepin, a tricyclic antidepressant was introduced in 1964 for the management of endogenous depression. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led the Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.

Биологическая активность

Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).

Контактные аллергены

This benzoxepin tricylcic drug has antidepressant, anticholinergic, antiitching, and antihistamine properties. After oral use, it has been developed as a topical antiitching agent. Allergic contact dermatitis is not infrequent.