Prallethrin

Химические свойства

solid

Использование

Prallethrin ia a synthetic pyrethroid; propynyl analog of allethrin. Prallethrin is used as an insecticide.

Опасность

A poison by ingestion and inhalation. Low toxicity by skin contact.

Фармаколо?гия

Prallethrin is a propynyl analog of allethrin, with 2-methyl-4-oxo-3-(prop-2-ynyl)-cyclopent-2-enyl as the secondary alcohol moiety that has been introduced against public health pests (113–115). The ester of the (S)-alcohol with (1R)-trans,cis-chrysanthemic acid resolved partially is commercialized on the strength of the assessment of insecticidal action of individual stereoisomers (116). Compared with d-allethrin, it is approximately four, six, and five times more effective on Musca domestica (for killing), Blattella germanica (for killing), and Culex pipiens pallens (for knockdown), respectively (43). A lower level of resistance to prallethrin than to phenoxybenzyl pyrethroids was demonstrated in a kdr-resistant housefly strain (116).

Профиль безопасности

A poison by ingestion and inhalation. Low toxicity by skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.

Метаболический путь

Prallethrin is stable under normal room temperature storage conditions for up to 36 months. It is labile to alkali at the ester linkage, forming 2 and 3 (Scheme 1). Analogy with the allethrins (from which it differs only in the degree of unsaturation in the side chain - propyne rather than propene) would suggest that the compound is very photolabile.