Декстрин

Химические свойства

Dextrin is partially hydrolyzed maize (corn), potato or cassava starch. It is a white, pale yellow or brown-colored powder with a slight characteristic odor.

Использование

dextrin (British gum; starch gum) absorbs moisture. It is also used as a binder to control product viscosity and reduce the density of a cosmetic. This powder is produced from corn starch and modified by means of a bacterial process. It may cause an allergic reaction.

Определение

A polysaccharide sugar produced by the action of amylase enzymes on or the chemical hydrolysis of starch. Dextrins are used as adhesives.

Методы производства

Dextrin is prepared by the incomplete hydrolysis of starch by heating in the dry state with or without the aid ofsuitable acids and buffers; moisture may be added during heating. The PhEur 6.4 specifies that dextrin is derived from maize(corn),potatoorcassava starch. A specification for cassava is included in the USP32–NF27.

преимущество

Slows sugar absorption (suppresses post-meal blood sugar rise); 
Intestinal healing effect; 
Slows fat absorption (suppresses post-meal triglyceride rise in the blood);
Reduction of visceral fat; 
Promotion of mineral absorption.

Общее описание

Dextrin is basically a sweet sugar extracted from potato starch. Dextrin color range is from white to tan; it has low to high solubilities in cold water, and gives pastes that vary widely in viscosity. It is produced from all commercial grain and tuber starches. During its manufacture, the factors taken into consideration are type of starch and moisture content, roasting time and temperature, and the type and amount of catalyst used.

Сельскохозяйственное использование

Dextrin is a group of colloidal products, formed by the hydrolysis of starches with dilute acids or by heating dry starch. The yellow or white powder or granules obtained are soluble in boiling water and insoluble in ether or alcohol. Dextrin is used in adhesives, as thickening agents and in penicillin manufacture.

Фармацевтические приложения

Dextrin is a dextrose polymer used as an adhesive and stiffening agent for surgical dressings. It is also used as a tablet and capsule diluent; as a binder for tablet granulation; as a sugar-coating ingredient that serves as a plasticizer and adhesive; and as a thickening agent for suspensions.
Additionally, dextrin has been used as a source of carbohydrate by people with special dietary requirements because it has a low electrolyte content and is free of lactose and sucrose.
Dextrin is also used in cosmetics.

Профиль безопасности

Mdly toxic by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes.

Безопасность

Dextrin is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. Larger quantities are used as a dietary supplement without adverse effects, although ingestion of very large quantities may be harmful.
LD50 (mouse, IV): 0.35g/kg

хранилище

Physical characteristics of dextrin may vary slightly depending on the method of manufacture and on the source material. In aqueous solutions, dextrin molecules tend to aggregate as density, temperature, pH, or other characteristics change. An increase in viscosity is caused by gel at ion or retro gradation as dextrin solutions age,and is particularly noticeable in the less-soluble maize starch dextrins. Dextrin solutions are thixotropic, becoming less viscous when sheared but changing to a soft paste or gel when allowed to stand. However, acids that are present in dextrin as residues from manufacturing can cause further hydrolysis, which results in a gradual thinning of solutions. Residual acid, often found in lesssoluble dextrins such as pyrodextrin, will also cause a reduction in viscosity during dry storage. To eliminate these problems, dextrin manufacturers neutralize dextrins of low solubility with ammonia or sodium carbonate in the cooling vessel.
The bulk material should be stored in a well-closed container in a cool, dry place.

Несовместимости

Incompatible with strong oxidizing agents.

Регуляторный статус

GRAS listed.Included in the FDA Inactive Ingredients Database(IV injections, oral tablets and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.