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Chloramphenicol palmitate
- русский язык имя
- английское имяChloramphenicol palmitate
- CAS №530-43-8
- CBNumberCB0437291
- ФормулаC27H42Cl2N2O6
- мольный вес561.54
- EINECS208-477-9
- номер MDLMFCD00083597
- файл Mol530-43-8.mol
химическое свойство
Температура плавления | 90 C |
альфа | D26 +24.6° (c = 5 in ethanol) |
Температура кипения | 691.6±55.0 °C(Predicted) |
плотность | 1.2354 (rough estimate) |
показатель преломления | 1.7350 (estimate) |
температура хранения | Store at RT. |
растворимость | DMSO (Slightly), Ethanol (Sparingly), Ethyl Acetate (Slightly) |
пка | 10.69±0.46(Predicted) |
форма | Solid |
цвет | White to Off-White |
Растворимость в воде | 8.423ug/L(25 ºC) |
λмакс | 271nm(EtOH)(lit.) |
Мерк | 14,2077 |
БРН | 2826438 |
Стабильность | Hygroscopic |
Справочник по базе данных CAS | 530-43-8(CAS DataBase Reference) |
FDA UNII | 43VU4207NW |
Коды опасности | Xn |
Заявления о рисках | 40-36/37/38-20/21/22 |
Заявления о безопасности | 36/37-36-26 |
WGK Германия | 3 |
RTECS | RT4735000 |
кода HS | 29414000 |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H351:Предполагается, что данное вещество вызывает раковые заболевания.
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оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
Chloramphenicol palmitate химические свойства, назначение, производство
Описание
Chloramphenicol palmitate is an orally bioavailable ester prodrug form of the antibiotic chloramphenicol. It is hydrolyzed in the small intestine to release chloramphenicol. Formulations containing chloramphenicol palmitate were previously used in the treatment of severe bacterial infections.Химические свойства
white crystalsИспользование
Chloramphenicol palmitate is prepared by acylation of chloramphenicol with palmitic acid. Although chloramphenicol palmitate is a more hydrophobic drug which should enhance bioavailability, the primary advantage of the ester is to mask the taste of chloramphenicol in oral formulations. Chloramphenicol palmitate is significantly less active than chloramphenicol but acts as a prodrug, being readily hydrolysed by acid and esterase in the gut to release chloramphenicol.прикладной
Chloramphenicol palmitate was synthesized by Parke Davis Co. in 1952. It has a much less bitter taste than chloramphenicol and is suitable for oral administration, especially for children. The palmitate shows a higher serum level after oral administration than chloramphenicol does and acts the same as chloramphenicol in vivo.Общее описание
Chloramphenicol palmitate is the palmitic acid ester ofchloramphenicol. It is a tasteless prodrug of chloramphenicolintended for pediatric use. The ester must hydrolyze invivo following oral absorption to provide the active form.Erratic serum levels were associated with early formulationsof the palmitate, but the manufacturer claims that thebioavailability of the current preparation is comparable tothat of chloramphenicol itself.Профиль безопасности
Moderately toxic by oral route. An experimental teratogen. Other experimental reproductive effects. An antibiotic. When heated to decomposition it emits very toxic fumes of NOx and Cl-. See also other chloramphenicol entries.Методы очистки
The palmitate crystallises from *benzene or xylene with m 105-106o and [] D –39.5o (c 2, Et2O), max 267.3nm. [Edgerton et al. J Am Chem Soc 77 27 1955, Beilstein 13 IV 2753.]Chloramphenicol palmitate запасные части и сырье
Chloramphenicol palmitate поставщик
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