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Изопропиловый пальмита
- английское имяIsopropyl palmitate
- CAS №142-91-6
- CBNumberCB0451826
- ФормулаC19H38O2
- мольный вес298.5
- EINECS205-571-1
- номер MDLMFCD00008993
- файл Mol142-91-6.mol
Температура плавления | 11-13 °C (lit.) |
Температура кипения | 160°C 2mm |
плотность | 0.852 g/mL at 25 °C (lit.) |
давление пара | 0.007Pa at 25℃ |
показатель преломления | n |
Fp | >230 °F |
температура хранения | 2-8°C |
растворимость | <0.001g/l |
форма | <11°C Solid,>13°C Liquid |
цвет | Colourless |
Запах | very sl. odor |
Растворимость в воде | Not miscible or difficult to mix with water. |
БРН | 1786567 |
ИнЧИКей | XUGNVMKQXJXZCD-UHFFFAOYSA-N |
LogP | 8.16 |
Справочник по базе данных CAS | 142-91-6(CAS DataBase Reference) |
Вещества, добавляемые в пищу (ранее EAFUS) | ISOPROPYL PALMITATE |
FDA 21 CFR | 310.545 |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | 8CRQ2TH63M |
Справочник по химии NIST | Isopropyl palmitate(142-91-6) |
Система регистрации веществ EPA | Isopropyl palmitate (142-91-6) |
Информация о косметике | Isopropyl Palmitate |
Коды опасности | Xi | |||||||||
Заявления о рисках | 36/38-36/37/38 | |||||||||
Заявления о безопасности | 26-36 | |||||||||
WGK Германия | - | |||||||||
RTECS | RT4900000 | |||||||||
TSCA | Yes | |||||||||
кода HS | 29157090 | |||||||||
Банк данных об опасных веществах | 142-91-6(Hazardous Substances Data) | |||||||||
Токсичность | mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689, | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
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P264:После работы тщательно вымыть кожу.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P332+P313:При возникновении раздражения кожи: обратиться за медицинской помощью.
P337+P313:Если раздражение глаз не проходит обратиться за медицинской помощью.
Изопропиловый пальмита химические свойства, назначение, производство
Химические свойства
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C.Использование
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.Определение
ChEBI: Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a fatty acid ester and an isopropyl ester. It is functionally related to a hexadecanoic acid.Методы производства
Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.Общее описание
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Фармацевтические приложения
Isopropyl palmitate is a nongreasy emollient with good spreading characteristics, used in topical pharmaceutical formulations and cosmetics such as: bath oils; creams; lotions; make-up; hair care products; deodorants; lip products; suntan preparations; and pressed powders.Isopropyl palmitate is an established penetration enhancer for transdermal systems. It has also been used in controlled-release percutaneous films. Table I: Uses of isopropyl palmitate
Побочные эффекты
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided.
Безопасность
Isopropyl palmitate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.LD50 (mouse, IP): 0.1 g/kg
хранилище
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16°C, and protected from light.Регуляторный статус
Included in the FDA Inactive Ingredients Database (topical and transdermal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.Изопропиловый пальмита запасные части и сырье
Изопропиловый пальмита поставщик
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