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N-Ацетил-D-глюкозамин
- английское имяN-Acetyl-D-Glucosamine
- CAS №7512-17-6
- CBNumberCB0320700
- ФормулаC8H15NO6
- мольный вес221.21
- EINECS231-368-2
- номер MDLMFCD00136044
- файл Mol7512-17-6.mol
химическое свойство
Температура плавления | 211 °C (dec.) (lit.) |
альфа | 42 º (c=2,water,2 hrs) |
давление пара | 8Pa at 20℃ |
показатель преломления | +39.0 to +42.0 ° (C=1, H2O) |
температура хранения | -20°C |
растворимость | Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents. |
форма | saline suspension |
Температура кипения | 636.4±55.0 °C(Predicted) |
плотность | 1.54 g/cm3 |
пка | 13.04±0.20(Predicted) |
цвет | white to off-white |
оптическая активность | Alpha type +75 → +41 Beta type -22 → +41.3 |
Растворимость в воде | H2O: 50 mg/mL colorless to faint yellow solution, clear to very slightly hazy |
Чувствительный | Hygroscopic |
Мерк | 14,4458 |
БРН | 1727589 |
Стабильность | Stable. Incompatible with strong oxidizing agents. |
ИнЧИКей | OVRNDRQMDRJTHS-ROGOILFBSA-N |
LogP | -2.2 at 23.7℃ |
Справочник по базе данных CAS | 7512-17-6(CAS DataBase Reference) |
FDA UNII | V956696549 |
Система регистрации веществ EPA | N-Acetylglucosamine (7512-17-6) |
больше
Коды опасности | Xi | |||||||||
Заявления о рисках | 36/37/38 | |||||||||
Заявления о безопасности | 24/25-36-26-22 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | LZ6651000 | |||||||||
F | 3-10 | |||||||||
Примечание об опасности | Irritant | |||||||||
TSCA | Yes | |||||||||
кода HS | 29329985 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H314:При попадании на кожу и в глаза вызывает химические ожоги.
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оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P310:Немедленно обратиться за медицинской помощью.
N-Ацетил-D-глюкозамин химические свойства, назначение, производство
Описание
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Химические свойства
White powderИспользование
N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.Определение
ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.Общее описание
N-Acetylglucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-Ацетил-D-глюкозамин запасные части и сырье
запасной предмет
N-Ацетил-D-глюкозамин поставщик
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