What is the alkylation of 1,2,4-triazole?

The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Using DBU as a base in the alkylation of 1,2,4-triazoles allows for the convenient and high-yielding synthesis of 1-substituted 1,2,4-triazoles.

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