What drugs contain a 1,2,4-triazole skeleton?

Triazole is an important heterocyclic compound with three nitrogen atoms in its five-membered ring. Its molecular formula is C2H3N3, and it is an isostere of amides, esters, and carboxylic acids. Depending on the position of the nitrogen atoms in the five-membered ring, triazole has two possible isomers, namely 1,2,3-triazole and 1,2,4-triazole.

1,2,4-Triazole (CAS: 288-88-0) is one of the most important scaffold compounds and a fundamental building block of many drugs. As the primary pharmacophore, it binds to biological receptors through hydrogen bonding and dipole-dipole interactions, exhibiting a wide range of potential pharmacological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, analgesic, anticancer, antihypertensive, antibiotic, anti-HIV, anti-manial, antioxidant, and anticonvulsant activities. 1,2,4-Triazole can be used as the main ingredient in the preparation of various clinical therapeutic drugs, such as terconazole, itraconazole, fluconazole, bittertanol, cyproconazole (fungicides), trazodone (anti-depressant) and triazolam (sedative and hypnotic), etc.

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