What does Hexapeptide-11 do for skin and hair?

Hexapeptide-11 has been shown to be effective in improving skin elasticity, enhancing nuclear accumulation of Nrf2, increasing proteasomal peptidase activity, inhibiting cellular senescence and facilitating the conversion of young vellus hairs into mature terminal hairs, which is important for skin and hair.

Hexapeptide-11 is a synthetic peptide that can be prepared by biofermentation. According to previous studies, Hexapeptide-11 upregulates key genes responsible for collagen production and important extracellular matrix components such as hyaluronic acid in human dermal fibroblasts. Topical application of Hexapeptide-11 was also able to upregulate the androgen receptor gene (AR), suggesting that Hexapeptide appears to be able to bind to the androgen receptor in the same way as testosterone. This suggests that hexapeptide-11 may be able to influence the major biochemical pathway that converts young vellus hairs into mature parietal hairs.

In vitro studies have also demonstrated that Hexapeptide-11 promotes dose- and time-dependent activation of genes involved in proteasome, autophagy, chaperone, and antioxidant responses.Hexapeptide-11 enhances nuclear accumulation of Nrf2, induces higher expression levels of proteasomal protein subunits, and improves proteasomal peptidase activity.Hexapeptide-11 Hexapeptide-11 is non-toxic to human fibroblasts and also inhibits oxidative stress-mediated premature cellular senescence. In an in vivo skin deformation assay, Hexapeptide-11 improved skin elasticity, suggesting that it improves underlying matrix proteins such as collagen and elastin. All of these functions are important for improving scalp and hair follicle health.

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