Benefits and applications of Hexapeptide-11

Hexapeptide-11 is a bio fermented peptide that has been shown in studies, run on human dermal fibroblasts, to upregulate key genes responsible for collagen production and important extracellular matrix components such as hyaluronic acid.

Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin.

Applications

Face creams, body creams, eye creams;

Body washes and cleansers;

Facial moisturizers;

All anti-aging products.

Benefits 

Hexapeptide-11 is a natural peptide (derived from baker`s yeast) shown in clinical studies to promote collagen and elastin formation, helping to firm and maintain skin integrity.

Hexapeptide-11 exhibits no significant toxicity in normal human diploid lung or skin fibroblasts. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities.

In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity. Finally, Hexapeptide-11 was found to induce the activity of extracellular MMPs and it also suppressed cell migration. Our presented findings indicate that Hexapeptide-11 is a promising anti-ageing agent.

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