Discover the mysterious skincare "little guard": the magical journey of 2-Methyl-4-isothiazolin-3-one

Abstract

In our daily lives, whether it is facial cleanser, shower gel, sunscreen, or hair conditioner, we cannot leave a small guardian that silently guards our skin health - preservatives. Among these preservatives, 2-Methyl-4-isothiazolin-3-one(MIT) has become a concerned role because of its unique bactericidal effect and wide range of applications.

Introduction

2-Methyl-4-isothiazolin-3-one(MIT) is an organic compound with the chemical formula C₄H₅NOS and a molecular weight of 115.15. This white-to-yellow powdery substance, with a certain smell, has amazing bactericidal power. As an efficient, broad-spectrum fungicide, it can inhibit the growth of bacteria, fungi, mold, and other microorganisms, and protect our skin health.

Uses

2-Methyl-4-isothiazolin-3-one (MIT), finds application in domestic and I & I cleaners, whereas the same product in combination with 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) is an established preservative in personal care and cosmetic products.

1,2-Benzisothiazolin-3-one (BIT) also has biocidal activity but is more commonly used in metal working/cutting oil applications.

Hazards

2-Methyl-4-isothiazolin-3-one (MIT) is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.

Reference

1. A. Schnuch, J. Geier, W. Utur, P. J. Frosch: "Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study", British Journal of Dermatology, 137(3), 467–476 (1998).

2. A. C. De Groot, A. Herxheimer: "Isothiazolinone Preservative: Cause Of A Continuing Epidemic Of Cosmetic Dermatitis", The Lancet, Volume 333, Issue 8633, 314–316 (1989).

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