2-Dimethylaminoisopropyl chloride hydrochloride: properties, applications and safety

General Description

2-Dimethylaminoisopropyl chloride hydrochloride is a white crystalline compound used as an intermediate in the pharmaceutical industry for the synthesis of Mexiletine and Pheniramine. It has a melting point range of 187-195℃ and is highly soluble in water. However, it poses significant safety hazards, including acute toxicity if swallowed, skin irritation, eye damage, and respiratory tract irritation if inhaled. It also poses a hazard to aquatic life. Proper safety precautions must be followed when handling this compound. In case of exposure, immediate medical attention is necessary, and vomiting should not be induced without medical guidance. Overall, caution is essential when dealing with this substance to prevent harm.

Figure 1. 2-Dimethylaminoisopropyl chloride hydrochloride

Properties

2-Dimethylaminoisopropyl chloride hydrochloride is a white crystalline solid with a melting point range of 187-195 ℃ (lit.) and a color ranging from white to pale creamy. It is highly soluble in water, with a solubility of 2000 g/L at a temperature of 20 ℃, and has a pH value of 5-6 when dissolved in water. Its molecular formula is C5H13Cl2N and its molecular weight is 158.07. This compound is sensitive to moisture and should be stored at room temperature. Its properties include being hygroscopic, meaning it readily absorbs moisture from the air. 2-Dimethylaminoisopropyl chloride hydrochloride is commonly used as a chemical intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Its high solubility in water makes it a useful reagent in various aqueous reactions. Overall, it has several important properties that make it a valuable component in a range of industrial and scientific applications. ¹

Applications

2-Dimethylaminoisopropyl chloride hydrochloride is a chemical compound widely used in the pharmaceutical industry. It serves as an intermediate in the production of two important drugs: Mexiletine and Pheniramine. Mexiletine is a central nervous system depressant used to treat various cardiac arrhythmias. It works by blocking sodium channels, thereby reducing the activity of the heart muscle and regulating the heart's rhythm. 2-Dimethylaminoisopropyl chloride hydrochloride acts as a crucial precursor in the synthesis of Mexiletine, playing a vital role in its manufacturing process. Pheniramine, on the other hand, is an antihistamine drug that is commonly used for the treatment of allergies, such as hay fever and allergic rhinitis. It helps to alleviate symptoms like sneezing, itching, and runny nose by blocking the effects of histamine in the body. 2-Dimethylaminoisopropyl chloride hydrochloride is utilized as an important intermediate in the production of Pheniramine. The applications of 2-Dimethylaminoisopropyl chloride hydrochloride in the pharmaceutical industry highlight its significance as an intermediate compound for the synthesis of these important drugs. Its role in the production of Mexiletine and Pheniramine showcases its contribution to the development of medications that aid in controlling cardiac arrhythmias and alleviating allergy symptoms. ²

Safety

2-Dimethylaminoisopropyl chloride hydrochloride is a chemical compound that presents potential safety hazards. The substance is classified as toxic if swallowed and harmful if ingested, causing acute toxicity and harm. Direct contact with the substance causes skin irritation and significant eye damage. Inhalation of the compound may result in respiratory tract irritation. In addition, it poses a substantial hazard to aquatic life, with both acute and long-term effects. Proper safety precautions should be taken when handling the compound to prevent exposure. The substance emits toxic fumes when heated, such as carbon monoxide, carbon dioxide, nitrogen oxides, and hydrogen chloride gas, which can cause severe health problems. In case of exposure, urgent medical attention should be sought, including immediate removal of contaminated clothing, rinsing affected areas with water or saline solution, and transportation to a hospital. It is crucial not to induce vomiting or apply any creams or medications without proper instructions from a doctor. Overall, it is essential to handle this substance with caution and follow appropriate safety measures to avoid potential harm. ³

Reference

1. PubChem. COMPOUND SUMMARY: 2-Dimethylaminoisopropyl chloride hydrochloride. National Library of Medicine, 2005, CID: 94294.

2. Singh S, Ahmad A, Raghuvanshi DS, Hasanain M, Agarwal K, Dubey V, Fatima K, Tandon S, Gupta A. Synthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4- methoxyphenyl)benzopyran-4-one derivatives as anticancer agents. Bioorganic and Medicinal Chemistry Letters, 2016, 26(21):5322-5327.

3. 2-chloropropyldimethylammonium chloride. European Chemicals Agency, EC / List no. 224-971-7.

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