SB 203580(SB203580)

SB 203580(SB203580)

S8307-1MG   2,008.89  SIGMA现货

信号转导蛋白抑制剂 SB 203580
S8307 - solid, ≥98% (HPLC)   

SB203580也写作SB 203580或SB-203580，是一种常用的p38 MAPK抑制剂。SB203580可以通透细胞，抑制p38 MAPK(p38 MAP kinase)，抑制后续MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通过抑制p38 MAPK，SB203580可以有效抑制一些炎症因子(如IL-1β、TNF-α)诱导的部分信号转导。SB203580选择性抑制p38 MAPK，IC50为600 nM；对于JNK/SAPK和p44/42 MAPK(即Erk1/2)无显著的抑制作用，IC50仅为100 μM。
    SB203580分子量为377.43，分子式为C21H16N3FOS，CAS Number：152121-47-6。本产品纯度大于99%。
保存条件：
    -20℃避光保存.
注意事项：
    SB203580对人体有刺激性，请注意适当防护。
    本SB203580在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。

[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole]

M.W. 377.43
 C21H16FN3OS
 [152121-47-6]
 

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Appearance:  white to off-white solid.  Disposal:  A

View the MSDS for this product

Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK.  This kinase is a homolog of MAP kinase.  Gallagher, T.F., et al.  "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis."  Bioorg. Med. Chem. Lett. 5:  1171-1176 (1995).  Cuenda, A., et al.  "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1."  FEBS Lett.. 364:  229-233 (1995).  Hazzalin, C.A., et al.  "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli."  Oncogene 15:  2321-2331 (1997).

Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.

参考资料：

U0126、SB203580、PD98059、LY294002对体外缺氧状态下A549细胞侵袭力的影响

丝裂原活化蛋白激酶(MAPK)抑制剂对人精子活动力的影响