6-甲基香豆素|T5647

6-Methylcoumarin
92-48-8

￥99 1mL 起订

上海更新日期：2026-01-06

TargetMol中国（陶术生物）

VIP13年

联系人：邵小姐

电话：021-021-33632979拨打

手机：15002134094 拨打

邮箱：marketing@targetmol.com

产品详情:

中文名称：: 6-甲基香豆素

英文名称：: 6-Methylcoumarin

CAS号：: 92-48-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 99.80%

产品类别：: 抑制剂

货号：: T5647

Product Introduction

Bioactivity

名称	6-Methylcoumarin
描述	6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.
细胞实验	The determination of in vitro intestinal permeability of 6MC was carried out under sink conditions in a series of pH-gradient bidirectional transport experiments with Caco-2 cells. Before the experiments, cell monolayers were rinsed with Hank's balanced salt solution (HBSS) and equilibrated for 30 min at 37 °C. The integrity of the monolayers was assessed before and after the experiments, by transepithelial electrical resistance (TEER) measurement. Only monolayers with TEER values above 200 Ωcm2 were considered. A stock solution of 6MC (10 mM DMSO) was diluted to final concentration of 10, 25, 50 or 100 μM in HBSS pH 6.5 (apical transport buffer) or pH 7.4 (basolateral transport buffer). Bidirectional experiments (apical-to-basolateral [AB] and basolateral-to-apical [BA]) were initiated by adding 6MC solutions to the donor compartment, and fresh buffer to the acceptor compartment. Caco-2 cell monolayers were incubated for 1 h at 37 °C under constant stirring (150 rpm). Receiver compartments were sampled at 0, 15, 30, 45 and 60 min, refilled with an equivalent amount of transport buffer, and samples were submitted to analysis by HPLC/UV.
体外活性	通过与Caco-2细胞的运输实验表明，在所有评估的浓度下，6MC展现了高渗透性。这暗示6MC可能通过被动扩散过程跨越肠壁运输。
体内活性	6-Methylcoumarin（6MC）可通过被动扩散过程跨越肠壁。口服途径时，最大浓度（Cmax）为17.13 ± 2.90 μg/mL，达到最大浓度的时间（Tmax）为30分钟；而通过腹膜内给药时，Cmax为26.18 ± 2.47 μg/mL，达到最大浓度的时间为6.0分钟。6MC的消除常数（Ke）为0.0070 min^-1，半衰期（T1/2）小于120分钟。6MC在肝脏中高度积累，并在所评估的所有器官中广泛分布。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (12.49 mM), Sonication is recommended. DMSO : 55 mg/mL (343.39 mM), Sonication is recommended.
关键字	Inhibitor \| inhibit \| 6-Methylcoumarin \| 6Methylcoumarin \| 6 Methylcoumarin
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Toncarine|||6-甲基香豆素|TargetMol

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成立日期	(13年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子