aladdin 阿拉丁 A408881 AS-604850 648449-76-7 10mM in DMSO

中文名：AS-604850

英文名：AS-604850

英文别名：(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

纯度：10mM in DMSO

货号：A408881

包装：1ml

Cas号：648449-76-7

存储温度：-80℃储存

产品介绍：

Information

AS-604850 is a selective, ATP-competitivePI3Kγinhibitor withIC50of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.
In vitro

AS-604850 is ATP-competitive PI3Kγ inhibitor with K_i values of 0.18 μM. AS-604850 is isoform selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα. (PI3Kα: IC50 = 4.5 μM, PI3Kγ and β: IC50 > 20μM) AS-604850 is capable of inhibiting C5a-mediated PKB phosphorylation in RAW264 mouse macrophages with an IC50 with 10 μM. AS-604850 blocks MCP-1-mediated chemotaxis in Pik3cg ^+/+ monocytes in a concentration- dependent manner, with an IC50 of 21 mM, but dosn\'t affect chemotaxis in Pik3cg^-/- cells, indicating that AS-604850 acts through PI3Kγ. AS-604850 diminishes glycochenodeoxycholate (GCDC) induced Akt-phosphorylation and apoptosis in rat hepatocytes. AS-604850 diminishes bile salt-induced apoptosis in HepG2 Ntcp and Huh7-Ntcp cells. AS604850 causes a concentration-dependent suppression of chemotactic responses of EoL-1 cells and blood eosinophils to platelet-activating factor (PAF).

In vivo

AS-604850 reduces RANTES-induced peritoneal neutrophil recruitment with a ED50 of 42.4 mg/kg. In the thioglycollate-induced peritonitis model, oral administration of 10 mg/kg AS-604850 results in a 31% reduction of neutrophil recruitment.
Cell Data

cell lines：

Concentrations：2.5 μM

Incubation Time：2 - 4 hours

Powder Purity:≥99%

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