Isoflupredone Acetate

Product NameIsoflupredone Acetate
CAS338-98-7
MFC23H29FO6
MW420.47
EINECS206-423-9
MOL File338-98-7.mol

Chemical Properties

Melting point	244-246° (dec)
alpha	D23 +108° (c = 0.735 in dioxane)
Boiling point	576.5±50.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly)
pka	12.05±0.70(Predicted)
form	Solid
color	White to Off-White
InChIKey	ZOCUOMKMBMEYQV-BZIJPSHGNA-N
SMILES	[C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C \|&1:0,10,12,14,17,19,22,r\|

Safety Information

HS Code

2937220000

Usage And Synthesis

Uses

Isoflupredone Acetate is an anti-inflammatory drug used in veterinary medicine. It is a corticosteroid with both glucocorticoid and mineralocorticoid activity and has been shown to increase the frequency of severe hypokalemia in healthy cows.

Definition

ChEBI: 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate is a corticosteroid hormone.

Veterinary Drugs and Treatments

Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids can be used for its antiinflammatory or immunosuppressive effects. Labeled indications for isoflupredone include: adjunctive treatment of bovine ketosis, alleviating pain and lameness associated with musculoskeletal conditions, acute hypersensitivity reactions, adjunctive treatment of overwhelming infections with severe toxicity, shock, supportive therapy in the treatment of stress conditions (e.g., surgery), dystocia, retained placenta, inflammatory ocular conditions, snakebite and parturient paresis.
In horses, isoflupredone has been used parenterally to reduce inflammation associated with recurrent airway obstruction (RAO, “heaves”, COPD).
While the drug could be used in small animals, it is recommended to use other glucocorticoid agents instead, where there has been more experience and other approved products for dogs and cats are available.

in vivo

Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline.html" class="link-product" target="_blank">Oxytetracycline (HY-B0275)^[2].

Animal Model:	96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)^[2]
Dosage:	0.05 mg/kg
Administration:	i.m.; on days 2 and 4 after the challenge
Result:	Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers. Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

Toxics Screening Level

The ITSL for Isoflupredone Acetate is 0.01 μg/m3 based on annual averaging.

Preparation Products And Raw materials

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