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Oxytetracycline dihydrate

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Oxytetracycline dihydrate Basic information
Oxytetracycline dihydrate Chemical Properties
  • Melting point:181-182 °C
  • alpha -216 º (c=1,0.1 M HCl)
  • storage temp. Sealed in dry,Room Temperature
  • solubility 1 M HCl: 0.1 M yellow to yellow-orange, clear
  • form crystalline
  • color yellow
  • Water Solubility slightly soluble
  • CAS DataBase Reference6153-64-6(CAS DataBase Reference)
  • EPA Substance Registry SystemOxytetracycline dihydrate (6153-64-6)
Safety Information
Oxytetracycline dihydrate Usage And Synthesis
  • Chemical Propertiesyellow crystalline powder
  • UsesAntibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial.
  • Usesantihypertensive
  • brand nameTerramycin (Pfizer).
  • Purification MethodsTerramycin crystallises (as dihydrate) from water or aqueous EtOH and is soluble in MeOH, EtOH, Me2CO and H2O (0.25mg/mL at 25o ) but insoluble in Et2O and pet ether. It is amphoteric, and an aqueous solution has pH 2.0-5.0. It has max at 247, 275 and 353nm in 0.1 M phosphate (pH 4.5). [Finlay et al. Science 111 85 1951.] The hydrochloride, [2058-46-0] M 496.9 [Beilstein 14 IV 2630], crystallises from MeOH in needles and from H2O at 50o it forms plates. Terramycin has also been purified via the hydrochloride by dissolving it in H2O, adjusting to pH 6, and the solid is filtered off after 1hour. The crystals of the dihydrate are dried to constant weight in vacuum/CaCl2/25o. Drying at 60o in vacuo gives the anhydrous base m 184.5-185.5o (sintering at 180o). The dihydrate has m 181-182o. Its optical rotation in MeOH decreases from [] D 25 +26o (c 0.5%) to [] D 25 +11.3o after standing for 16hours. It forms a sodium salt and a CaCl2 complex. [Regna et al. J Am Chem Soc 73 4211 1951, Beilstein 14 IV 2633.]
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