Sulfamerazine sodium

Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.

Involved in characterization of chirosan membranes for the transport of drugs1,2,3

Bio hubber simple;Cremo-merazine;Debnal m;Mebacid;Neotrizine;Peccocode;Septosil;Spanbolet ii;Tersulpha;Trisulfaminic;Trisulpha.

Sulfamerazine sodium, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in some countries usually in combination with other sulfonamides.

Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.

[1] SUMMERS W A. The effects of oral administration of aureomycin, sulfathiazole, sulfamerazine and 4,4’-diamino diphenyl sulfone on toxoplasmosis in mice.[J]. American Journal of Tropical Medicine and Hygiene, 1949, 29 6: 889-893. DOI: 10.4269/ajtmh.1949.s1-29.889
[2] ZHANHUI WANG . A highly sensitive and class-specific fluorescence polarisation assay for sulphonamides based on dihydropteroate synthase[J]. Biosensors and Bioelectronics, 2015, 70: Pages 1-4. DOI: 10.1016/j.bios.2015.03.016
[3] MARIYA AL RASHIDA. Sulfa drugs as inhibitors of carbonic anhydrase: new targets for the old drugs.[J]. BioMed Research International, 2014: 162928. DOI: 10.1155/2014/162928
[4] S MATSUSHITA  E S. Prevention and treatment of cilia-associated respiratory bacillus in mice by use of antibiotics.[J]. Laboratory animal science, 1995, 45 5: 503-507.