Basic information Brand Name(s) in US Safety Related Supplier
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Sulfadimethoxine

Basic information Brand Name(s) in US Safety Related Supplier
Sulfadimethoxine Basic information
Sulfadimethoxine Chemical Properties
  • Melting point:200 °C
  • Boiling point:265.5°C (rough estimate)
  • Density 1.4006 (rough estimate)
  • refractive index 1.6270 (estimate)
  • storage temp. 2-8°C
  • solubility NH4OH 1 M: 50 mg/mL, clear, faintly yellow
  • form neat
  • pkapKa 5.94(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
  • Water Solubility 46.3mg/L(37 ºC)
  • Merck 14,8905
  • BRN 306856
  • CAS DataBase Reference122-11-2(CAS DataBase Reference)
  • EPA Substance Registry SystemSulfadimethoxine (122-11-2)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38-43
  • Safety Statements 26-36/37-24/25-23
  • RIDADR 3249
  • WGK Germany 3
  • RTECS WO9030000
  • 8
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29350090
  • ToxicityLD50 orally in mice: >10 g/kg (Seki)
MSDS
Sulfadimethoxine Usage And Synthesis
  • Brand Name(s) in USAlbon, Bactrovet, and generic
  • Chemical PropertiesWhite Solid
  • OriginatorMadribon,Roche,US,1958
  • UsesAntibacterial.
  • DefinitionChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
  • Manufacturing Process1.4 g of 4-phenylsulfonyl-2,6-dimethoxypyrimidine and 4 g of sodium sulfanilamide (both dried over potassium hydroxide) were very finely ground and heated in an oil bath for 10 hours at 120°C (inside temperature). The reaction mixture was taken up in 30 ml of water and treated with 3 ml of 2 N sodium hydroxide solution. After standing for one hour at 0°C, the turbid solution was filtered and the filtrate was made alkaline with sodium carbonate. After again standing for one hour at 0°C, the precipitate was filtered off (1.9 g of regenerated sulfanilamide) and the filtrate was neutralized with acetic acid, whereupon crystallization resulted. The isolated crystals of 4-sulfanilamido- 2,6-dimethoxypyrimidine weighed 1.3 g (84% of theory), melting point 190°C to 196°C.
  • Therapeutic FunctionAntibacterial
  • Pharmaceutical Applications2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed compound with a long half-life (38–40 h) and a high degree of protein binding (98%). Renal clearance is very slow, and daily dosage maintains adequate plasma levels.
  • Safety ProfileModerately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Veterinary Drugs and TreatmentsSulfadimethoxine injection and tablets are approved for use in dogs and cats for respiratory, genitourinary, enteric and soft tissue infections caused by susceptible organisms. Sulfadimethoxine is used in the treatment of coccidiosis in dogs although not approved for this indication.
    In horses, sulfadimethoxine injection is approved for the treatment of respiratory infections caused by Streptococcus equi.
    In cattle, the drug is approved for treating shipping fever complex, calf diphtheria, bacterial pneumonia and foot rot caused by susceptible organisms.
    In poultry, sulfadimethoxine is added to drinking water to treat coccidiosis, fowl cholera, and infectious coryza.
Sulfadimethoxine(122-11-2)Related Product Information
SulfadimethoxineSupplierMore
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