Triazophos

Triazophos is a Yellowish-brown-oil chemical pesticide used as an insecticide, nematicide and acaricide. The chemical is an organophosphorus compound and ingestion and other exposures to the chemical can cause various symptoms. The type and severity of symptoms varies depending on the amount of chemical involved and the nature of the exposure. The chemical may be absorbed through the skin. More detailed information about the symptoms, causes, and treatments of Chemical poisoning--Triazophos is available below. It is stable to sunlight and its molecular weight313.312 g/mol. For solublity, It solubles in organic solvents and in acetone, dichloromethane, methanol, isopropanol, ethyl acetate and plyethyleneglycols >500; n-hexane 11.1 (all in g/L at 20 degree).

Triazophos is produced by reaction of 1-phenyl-3-hydroxy-1H-1,2,4-triazole, suspended in acetone, with diethoxythiophosphoryl chloride in the presence of triethylamine.
Physical and chemical properties
The pure product is a pale yellow-brown oily liquid; melting point: 0-5 °C; vapor pressure: 0.39 Mpa; relative density: 1.24; it decomposes at 185 °C before reaching the boiling point and can be degraded by acids and alkalis.

Triazophos is a broad-spectrum insecticide and miticide and has a certain degree of nematicidal effects. It has excellent preventive effects on many pests of the major crops including grain, cotton and vegetables, such as stem borers, rice planthoppers, spider mites, cotton bollworms, nematodes, and it is especially effective on the lepidoptera.

It should be protected from the sun, rain and heat sources and kept away from food, seeds and feeds.

1.http://www.sld.chemchina.com/slden/cpyfw/ppysb/jscg/webinfo/2012/06/1342611935442261.htm
2.https://pubchem.ncbi.nlm.nih.gov/compound/Triazophos
3.https://fr.wikipedia.org/wiki/Triazophos

The industrial product is a yellow liquid with a solubility of 30-40 mg/kg in water. It is easily soluble in acetone, ethyl acetate, and toluene.

Pesticide.

An organophosphorus insecticide.

Triazophos is used to control chewing and sucking insects and mites in a wide range of crops. It is also used to control some nematodes in ornamentals and strawberries.

ChEBI: Triazophos is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide, an agrochemical and a nematicide. It is functionally related to a 1-phenyl-1H-1,2,4-triazol-3-ol.

Yellowish oil. Used to control insects, mites, and nematodes. Not registered as a pesticide in the U.S.

Organophosphates, such as Triazophos, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

This is an organophosphate pesticide. Triazophos is a cholinesterase inhibitor and acts on the central nervous system. Organic phosphorus insecticides are absorbed by the skin as well as by the respiratory and gastrointestinal tracts.

This is an organophosphate pesticide. Some of these materials may burn but none of them ignite readily. Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Degraded by acids and alkalis.

Insecticide: Triazophos is a broad-spectrum insecticide and acaricide used to control sucking and chewing pests on a variety of crops, including cotton, rice, corn, beets and fruit trees. Not currently registered for use in the U.S. Not approved for use in EU countries . There are more than 30 global suppliers .

HILAZPOPHOS®; HOE 2960 OJ®; HOE 002960®; HOSTATHION®; SUTATHION®

I. Phenylhydrazine hydrochloride and urea were mixed and heated to 150-160 ?? with stirring, the reaction produced ammonia to get a yellow melt. Cooling, washing, filtration, recrystallization with alcohol to get 1-phenylaminourea (melting point 172 ??). 1-phenylaminourea, triethyl orthoformate and toluene were heated with stirring, and the ethanol generated by the reaction was evaporated until no ethanol was evaporated. After the reaction, cooling, filtration, washing, to obtain 1-phenyl-3-hydroxy-1,2,4-triazole (melting point 269-273 ??). 1-phenyl-3-hydroxy-1,2,4-triazole was suspended in acetone, O,O-diethylthiophosphoryl chloride was added, and then triethylamine was added dropwise. After dropwise addition, the reaction was stirred at 50 ??C for 6 h. The reaction was cooled, filtered and the triethylamine hydrochloride was filtered out. The filtrate recovered acetone to get triazophos brown oil.
Second, 33.5g96% of 1-phenyl-3-hydroxy-1,2,4-triazole suspended in 250mL xylene, add the appropriate amount of composite catalyst (TEBAT + DMAP) and potassium carbonate, stirring for 0.5h, and then dropwise addition of 30g of O,O - diethylthiophosphoryl chloride, the reaction temperature of 80 ~ ?? C, the reaction time of 4h, cooling, filtration, filtrate washed with water, drying. The yield reached 86%. Literature [5] describes the use of a BG catalyst, the yield reached 91% to 96%.

The main route of biotransformation of triazophos is degradation to 1- pheny1-3-hydroxy-1,2,4-triazole, probably either via hydrolysis of triazophos oxon or through oxidative cleavage of triazophos itself. The triazole ring of this metabolite is opened to give 1-phenylsemicarbazide and semicarbazide, both of which are conjugated in the rat and also degraded to urea as the main urinary metabolite.

Triazophos is stable to light but is hydrolysed by acids and alkalis (PM).