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Basic information Description References Safety Related Supplier
Azamethiphos Basic information
Azamethiphos Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36-40-21-67-36/37/38
  • Safety Statements 26-36/37-24/25-23
  • RIDADR UN 1593 6.1/PG 3
  • WGK Germany 3
  • RTECS TE8070000
  • HS Code 29349990
  • ToxicityLD50 orl-rat: 1180 mg/kg PEMNDP 9,44,91
Azamethiphos Usage And Synthesis
  • DescriptionAzamethiphos is an organothiophosphate insecticide. It can be used as a veterinary drug used in the salmon fish farming for controlling parasites such as salmon lice (Lepeophtheirus salmonis), a marine ectoparasitic copepod on salmonid species. Its primary target is on the acetylcholinesterase, a serine hydrolase involved in neurotransmission at cholinergic synapses and neuromuscular junctions.
  • ReferencesIntorre, L, et al. "Safety of azamethiphos in eel, seabass and trout." Pharmacological Research the Official Journal of the Italian Pharmacological Society 49.2(2004):171. Kaur, K, et al. "Mechanism behind Resistance against the Organophosphate Azamethiphos in Salmon Lice (Lepeophtheirus salmonis). " Plos One 10.4(2015):e0124220.
  • Chemical Propertieswhite to light yellow crystal powde
  • UsesAzamethiphos is used to control flies and other insect pests in animal houses and also public hygiene and health pests such as mosquitoes and cockroaches. It has recently been used to control sea lice in salmon.
  • UsesSynergistic insecticidal and acaricidal organophosphorus compound
  • Safety ProfileModerately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, SOx, POx, and Cl- .
  • Metabolic pathwayAzamethiphos is metabolised in mammals via hydrolysis, followed by opening of the oxazolinone ring and conjugation of the resultant aminopyridinol as the glucuronide and sulfate ester.
  • MetabolismAzamethiphos is metabolized via the cleavage of phosphorothiolate C?S bond, followed by N-demethylation and opening of the oxazolinone ring and conjugation of the resultant aminochloropyridinol as the glucuronide and sulfate ester.
  • Toxicity evaluationAcute oral LD50 for rats is 1180 mg/kg. Inhalation LC50 (4 h) for rats is >560 mg/m3 air. ADI is 0.025 mg/kg.
  • DegradationAzamethiphos is unstable in alkalis and acids. The DT50 values at pH 5,7 and 9 were 800,260 and 4.3 hours, respectively (PM).
Azamethiphos Preparation Products And Raw materials
Azamethiphos(35575-96-3)Related Product Information
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