2-Iodobenzaldehyde

• 2,3-diaryl-1-indenones
• indolo[1,2-a]quinazolines
• Baylis-Hillman (BH) adducts

• 5-phenylindazolo[3,2-b]quinazolin-7(5H)-one
• 4-(3-iodophenyl)-2,2:6,2-terpyridine
• fluoren-9-one
• 2-formyl-3′-methoxybiphenyl

40138-16-7

26260-02-6

General procedure for the synthesis of 2-iodobenzaldehyde from 2-formylphenylboronic acid: 2-formylphenylboronic acid (0.067 g, 0.4 mmol), copper powder (0.0052 g, 0.08 mmol), (CF3)2CFI (0.178 g, 0.6 mmol) and DMF (2 mL) were added to a closed tube with a rubber stopper. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the resulting suspension was poured into water and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (20:1, v/v) as eluent to give 0.086 g of 2-iodobenzaldehyde as a light yellow solid (0.35 mmol, 87% yield).