ChemicalBook > Product Catalog > API > Antipyretic analgesics > Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) > Pranoprofen
Pranoprofen
- Product Name:Pranoprofen
- CAS:52549-17-4
- MF:C15H13NO3
- MW:255.27
- EINECS:682-035-7
- Mol File:52549-17-4.mol
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Pranoprofen Chemical Properties
- Melting point:182-183°
- Boiling point:398.5°C (rough estimate)
- Density 1.1654 (rough estimate)
- refractive index 1.5500 (estimate)
- storage temp. 2-8°C
- pka4.27±0.10(Predicted)
- form powder
- color white to beige
- CAS DataBase Reference52549-17-4(CAS DataBase Reference)
- RIDADR UN 2811 6.1 / PGIII
- RTECS DJ3100950
- ToxicityLD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
Pranoprofen Usage And Synthesis
- Chemical PropertiesOff-White Solid
- OriginatorNiflan, Yoshitomi ,Japan ,1981
- UsesPranoprofen is an anti-inflammatory used in ophthalmology.
- Manufacturing ProcessA mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.
- Therapeutic FunctionAnalgesic, Antiinflammatory
- Folic acid 3-Phenylpropionic acid Ibuprofen l-Pranoprofen,(S)-(+)-Pranoprofen (R)-Pranoprofen,(R)-(-)-Pranoprofen,d-Pranoprofen ALFA-METHYL-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER 2-(4-METHOXY-3-METHYLPHENYL)ACETALDEHYDE N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate ALFA-METHYL-ALFA-CYANO-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER 4-METHOXY-3-METHYLPHENYLACETIC ACID Pranoprofen Ascoric Acid Centchroman Imidocarb dipropionate Propionic acid Nandrolone phenylpropionate 3-(4-Hydroxyphenyl)propionic acid Ethyl 2-(Chlorosulfonyl)acetate
PranoprofenSupplierMore
- Company Name:Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. Gold
- Tel:17701827760
- Email:starpharmsh@gmail.com
- Company Name:Hangzhou Langmai New Material Co., Ltd. Gold
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- Company Name:Guangdong Xianqiang Pharmaceutical Co., Ltd. Gold
- Tel:13509815581 020-87815159-
- Email:tanshuhua@xianqiang.com
- Company Name:J & K SCIENTIFIC LTD.
- Tel:400-666-7788 010-82848833-
- Email:jkinfo@jkchemical.com;market6@jkchemical.com
- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456-
- Email:sales@BioChemBest.com