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Pranoprofen

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Pranoprofen Basic information
Pranoprofen Chemical Properties
  • Melting point:182-183°
  • Boiling point:398.5°C (rough estimate)
  • Density 1.1654 (rough estimate)
  • refractive index 1.5500 (estimate)
  • storage temp. 2-8°C
  • pka4.27±0.10(Predicted)
  • form powder
  • color white to beige
  • CAS DataBase Reference52549-17-4(CAS DataBase Reference)
Safety Information
  • RIDADR UN 2811 6.1 / PGIII
  • RTECS DJ3100950
  • ToxicityLD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
Pranoprofen Usage And Synthesis
  • Chemical PropertiesOff-White Solid
  • OriginatorNiflan, Yoshitomi ,Japan ,1981
  • UsesPranoprofen is an anti-inflammatory used in ophthalmology.
  • Manufacturing ProcessA mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.
  • Therapeutic FunctionAnalgesic, Antiinflammatory
Pranoprofen(52549-17-4)Related Product Information
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